N-Acyloxyphthalimides as Nitrogen Radical Precursors in the Visible Light Photocatalyzed Room Temperature C-H Amination of Arenes and Heteroarenes

被引：359
作者：
Allen, Laura J. [1 ]
Cabrera, Pablo J. [1 ]
Lee, Melissa [1 ]
Sanford, Melanie S. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 15期
关键词：
METAL-FREE CONDITIONS; BOND FORMATION; PHOTOREDOX CATALYSIS; AMBIENT-TEMPERATURE; COUPLING REACTIONS; ORGANIC-SYNTHESIS; IMIDYL RADICALS; PALLADIUM; COPPER; AMIDATION;
D O I：
10.1021/ja501906x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper reports a room temperature visible light photocatalyzed method for the C-H amination of arenes and heteroarenes. A key enabling advance in this work is the design of N-acyloxyphthalimides as precursors to nitrogen-based radical intermediates for these transformations. A broad substrate scope is presented, including the selective meta-amination of pyridine derivatives. A radical aromatic substitution mechanism is proposed.
引用
收藏
页码：5607 / 5610
页数：4
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