Pathological Choice: The Neuroscience of Gambling and Gambling Addiction

被引:77
作者
Clark, Luke [1 ]
Averbeck, Bruno [2 ]
Payer, Doris [3 ]
Sescousse, Guillaume [4 ]
Winstanley, Catharine A. [5 ]
Xue, Gui [6 ,7 ]
机构
[1] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England
[2] NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA
[3] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON M5T 1R8, Canada
[4] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 HP Nijmegen, Netherlands
[5] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada
[6] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[7] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会; 英国医学研究理事会;
关键词
VENTROMEDIAL PREFRONTAL CORTEX; DECISION-MAKING; DOPAMINE RELEASE; COGNITIVE DISTORTIONS; RECEPTOR AVAILABILITY; ORBITOFRONTAL CORTEX; BASOLATERAL AMYGDALA; REWARD ANTICIPATION; NICOTINE DEPENDENCE; DRUG-ADDICTION;
D O I
10.1523/JNEUROSCI.3231-13.2013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Gambling is pertinent to neuroscience research for at least two reasons. First, gambling is a naturalistic and pervasive example of risky decision making, and thus gambling games can provide a paradigm for the investigation of human choice behavior and "irrationality." Second, excessive gambling involvement (i.e., pathological gambling) is currently conceptualized as a behavioral addiction, and research on this condition may provide insights into addictive mechanisms in the absence of exogenous drug effects. This article is a summary of topics covered in a Society for Neuroscience minisymposium, focusing on recent advances in understanding the neural basis of gambling behavior, including translational findings in rodents and nonhuman primates, which have begun to delineate neural circuitry and neurochemistry involved.
引用
收藏
页码:17617 / 17623
页数:7
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