Increasing the antibacterial activity of gallium(III) against Pseudomonas aeruginosa upon coordination to pyridine-derived thiosemicarbazones

被引：63

作者：

da Silva, Jeferson G. ^{[1
]}

Azzolini, Lucas S. ^{[1
]}

Wardell, Solange M. S. V. ^{[2
]}

Wardell, James L. ^{[1
]}

Beraldo, Heloisa ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

[2] Fiocruz MS, Inst Tecnol Farmacos, Dept Sintese Organ, BR-21041250 Rio De Janeiro, Brazil

来源：

POLYHEDRON | 2009年 / 28卷 / 11期

关键词：

Thiosemicarbazones; Gallium(III) complexes; Antibacterial; Pseudomonas aeruginosa; IN-VITRO; SPECTRAL CHARACTERIZATION; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.poly.2009.04.022

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of N(4)-phenyl-2-formlylpyridine thiosemicarbazone (H2Fo4Ph), N(4)-phenyl-2-acetylpyridine thiosemicarbazone (H2Ac4Ph) and N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) with gallium nitrate gave [Ga(H2Fo4Ph)(2)](NO3)(3) (1), [Ga(2Ac4Ph)(2)]NO3 (2) and [Ga(2Bz4Ph)(2)]NO3 (3). In all complexes coordination of the thiosemicarbazone via the N-py-N-S chelating system occurs. In I the thiosemicarbazone acts as a neutral ligand while in 2 and 3 the ligand is anionic. Upon Slow diffusion of 2 in DMSO [Ga(2Ac4Ph)(2)] NO3 center dot DMSO (2a) was formed. The crystal structure of 2a was determined. Upon coo coordination the antibacterial activity of both gallium and thiosemicarbazones against Pseudomonas aeruginosa significantly increases. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2301 / 2305

页数：5

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