Low birth weight as a potential risk factor for severe COVID-19 in adults

被引：15

作者：

Crispi, Fatima ^{[1
,2
]}

Crovetto, Francesca ^{[1
,2
]}

Larroya, Marta ^{[1
,2
]}

Camacho, Marta ^{[1
,2
]}

Tortajada, Marta ^{[1
,2
]}

Sibila, Oriol ^{[3
]}

Badia, Joan Ramon ^{[3
]}

Lopez, Marta ^{[1
,2
]}

Vellve, Kilian ^{[1
,2
]}

Garcia, Ferran ^{[4
]}

Trilla, Antoni ^{[5
]}

Faner, Rosa ^{[3
]}

Blanco, Isabel ^{[3
]}

Borras, Roger ^{[6
]}

Agusti, Alvar ^{[3
]}

Gratacos, Eduard ^{[1
,2
]}

机构：

[1] Univ Barcelona, Hosp Clin, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Sabino de Arana 1, Barcelona 08028, Spain

[2] Univ Barcelona, Hosp St Joan de Deu, IDIBAPS, Ctr Biomed Res Rare Dis CIBER ER, Sabino de Arana 1, Barcelona 08028, Spain

[3] Univ Barcelona, Hosp Clin, Spanish Network Biomed Res Resp Dis CIBERES, IDIBAPS,Resp Inst, Barcelona, Spain

[4] Hosp Clin Barcelona, Project Management & Web Domains, Barcelona, Spain

[5] Univ Barcelona, Hosp Clin, Prevent Med & Epidemiol, Barcelona, Spain

[6] Univ Autonoma Barcelona, Hosp Clin, Cardiovasc Inst, IDIBAPS, Barcelona, Spain

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

PRETERM BIRTH; GROWTH RESTRICTION; LUNG-FUNCTION; FETAL; DISEASE; CONSEQUENCES; PNEUMONIA; ORIGINS;

D O I：

10.1038/s41598-021-82389-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight <= 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P=0.012), male sex (aOR 3.39 [1.72-6.67], P<0.001), hypertension (aOR 3.37 [1.69-6.72], P=0.001), and LBW (aOR 3.61 [1.55-8.43], P=0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms.

引用

页数：8

共 45 条

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