Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women

Objective: The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status. Design and methods: The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI 32.4 +/- 6.4) and non-smokers (Group A), 40 non-overweight (BMI 22.6 +/- 1.8) and smokers (Group B) and 55 non-overweight (BMI 23.5 +/- 1.4) and non-smokers (Group Q. oxLDL and antibodies against them (anti-oxLDL) were measured using ELISA. Serum total cholesterol, LDL, HDL and triglycerides were measured in an automated analyzer. Results: Total cholesterol, LDL, HDL and oxLDL serum levels were significantly elevated in Group A as compared to Group B or C, as well as oxLDL in Group B in comparison to Group C (p < 0.001). Triglycerides and anti-oxLDL were increased in Group A in comparison to Group C (p = 0.043 and 0.023). Total cholesterol, LDL, triglycerides and anti-oxLDL did not differ between Groups B and C, while HDL was decreased in Group B as compared to Group C (p < 0.001). A significant positive correlation was found between oxLDL and LDL in Group A (r = 0.53, p < 0.001) as well as in Group C (r = 0.955, p < 0.001) and a negative one between oxLDL and HDL in Group C (r = -0.933, p < 0.001). Regression analysis revealed that obesity was a stronger predictor of LDL oxidation than smoking. Conclusions: Postmenopausal obesity is involved in the process of LDL oxidation and appears to be a stronger predictor of LDL oxidation than smoking. Future studies are needed to confirm these associations. (C) 2008 Elsevier Ireland Ltd. All rights reserved.