Chronobiology, excessive daytime sleepiness and depression: Is there a link?

被引：48

作者：

Chellappa, Sarah Laxhmi ^{[1
,2
]}

Schroeder, Carmen ^{[3
]}

Cajochen, Christian ^{[1
]}

机构：

[1] Psychiat Univ Clin, Ctr Chronobiol, CH-4025 Basel, Switzerland

[2] Minist Educ Brazil, CAPES Fdn, BR-70359970 Brasilia, DF, Brazil

[3] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA

来源：

SLEEP MEDICINE | 2009年 / 10卷 / 05期

关键词：

Daytime sleepiness; Sleep disorders; Depressive disorders; Light therapy; Sleep deprivation; Circadian rhythm; SEASONAL AFFECTIVE-DISORDER; DIURNAL MOOD VARIATION; BRAIN GLUCOSE-METABOLISM; CIRCADIAN-RHYTHMS; CONSTANT ROUTINE; PSYCHIATRIC-DISORDERS; BIPOLAR DEPRESSION; BRIGHT LIGHT; DEPRIVATION; PHASE;

D O I：

10.1016/j.sleep.2008.05.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：505 / 514

页数：10

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