New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides

被引：5
|
作者：
Colin, T [1 ]
El Kaïm, L [1 ]
Gaultier, L [1 ]
Grimaud, L [1 ]
Gatay, L [1 ]
Michaut, V [1 ]
机构：
[1] Ecole Natl Super Tech Avancees, Lab Chim & Proc, F-75015 Paris, France
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 29期
关键词：
trifluoromethyl group; pyruvamide; isocyanide; enamines;
D O I：
10.1016/j.tetlet.2004.05.128
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5611 / 5613
页数：3
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