Cancer vaccines in colon and rectal cancer over the last decade: lessons learned and future directions

被引：29

作者：

Berry, John ^{[1
,2
]}

Vreeland, Timothy ^{[2
,3
]}

Trappey, Alfred ^{[4
]}

Hale, Diane ^{[2
,4
]}

Peace, Kaitlin ^{[4
]}

Tyler, Joshua ^{[5
]}

Walker, Avery ^{[6
]}

Brown, Ramon ^{[5
]}

Herbert, Garth ^{[4
]}

Yi, Fia ^{[4
]}

Jackson, Doreen ^{[2
,4
]}

Clifton, Guy ^{[2
,4
,7
]}

Peoples, George E. ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Dept Colorectal Surg, St Louis, MO 63130 USA

[2] Canc Vaccine Dev Program San Antonio, San Antonio, TX USA

[3] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA

[4] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA

[5] Keesler Air Force Med Ctr, Dept Surg, Keesler AFB, MS USA

[6] Brian Allgood Army Community Hosp, Dept Surg, Seoul, South Korea

[7] Univ Texas MD Anderson Canc Ctr, Dept Surg, Houston, TX 77030 USA

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2017年 / 13卷 / 03期

关键词：

Cancer vaccine; colorectal cancer; immunotherapy; active specific immunotherapy; colon cancer; rectal cancer; dendritic cell vaccines; peptide vaccines; autologous tumor cell vaccines; viral vector vaccines; ACTIVE SPECIFIC IMMUNOTHERAPY; ANTIGEN; 5T4; TROVAX; TUMOR-CELL VACCINE; PERSONALIZED PEPTIDE VACCINATION; ADVANCED COLORECTAL-CANCER; PHASE-I; STAGE-II; MICROSATELLITE INSTABILITY; IMMUNE CELLS; TRIAL;

D O I：

10.1080/1744666X.2016.1226132

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: Great advances have been made in screening for and treatment of colorectal cancer (CRC), but recurrence rates remain high and additional therapies are needed. There is great excitement around the field of immunotherapy and many attempts have been made to bring immunotherapy to CRC through a cancer vaccine.Areas covered: This is a detailed review of the last decade's significant CRC vaccine trials.Expert commentary: Monotherapy with a CRC vaccine is likely best suited for adjuvant therapy in disease free patients. Vaccine therapy elicits crucial tumor infiltrating lymphocytes, which are lacking in microsatellite-stable tumors, and therefore may be better suited for these patients. The combination of CRC vaccines with checkpoint inhibitors may unlock the potential of immunotherapy for a much broader range of patients. Future studies should focus on vaccine monotherapy in correctly selected patients and combination therapy in more advanced disease.

引用

页码：235 / 245

页数：11

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