Ellagic acid protects Lipbpolysaccharide/D-galactosamine-induced acute hepatic injury in mice

被引：67

作者：

Gu, Lei ^{[1
]}

Deng, Wen-sheng ^{[1
]}

Liu, Ye ^{[1
]}

Jiang, Chun-hui ^{[1
]}

Sun, Long-ci ^{[1
]}

Sun, Xiao-fei ^{[1
]}

Xu, Qing ^{[1
]}

Zhou, Hong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Surg Gastroenterol, Shanghai 200127, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 22卷 / 02期

关键词：

Ellagic acid; Lipopolysaccharide (LPS); Nrf2; NF-kappa B; ACUTE LUNG INJURY; LIVER-INJURY; SIGNALING PATHWAY; OXIDATIVE STRESS; ANTIOXIDANT; FAILURE; RATS; APOPTOSIS; NEPHROTOXICITY; METABOLISM;

D O I：

10.1016/j.intimp.2014.07.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic add on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice. The results showed that LPS/GaIN increased hepatic malondialdehyde (MDA) content, TNF-alpha level, serum ALT and AST levels and TNF-alpha level. However, these changes were attenuated by ellagic acid. Western blot analysis showed that ellagic acid inhibited LPS/GaIN-induced NF-kappa B activation. Furthermore, ellagic acid induced the expression of Nrf2 and heme oxygenase-1. In conclusion, our results showed that ellagic acid protected against LPS/GaIN-induced liver injury by enhancing the antioxidative defense system and reducing inflammatory response. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：341 / 345

页数：5

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