P4 cap modified tetrapeptidyl α-ketoamides as potent HCVNS3 protease inhibitors

被引：17

作者：

Sun, DX ^{[1
]}

Liu, LF ^{[1
]}

Heinz, B ^{[1
]}

Kolykhalov, A ^{[1
]}

Lamar, J ^{[1
]}

Johnson, RB ^{[1
]}

Wang, QM ^{[1
]}

Yip, Y ^{[1
]}

Chen, SH ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Lab, Lilly Corp Ctr, Indianapolis, IN 46285 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 16期

关键词：

D O I：

10.1016/j.bmcl.2004.05.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4333 / 4338

页数：6

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