How I treat paediatric relapsed acute myeloid leukaemia

被引：24

作者：

Kaspers, Gertjan ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, NL-1081 HV Amsterdam, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2014年 / 166卷 / 05期

关键词：

prognosis; personalized therapy; targeted therapy; minimal residual disease; allogeneic stem cell transplantation; MINIMAL RESIDUAL DISEASE; ACUTE MYELOGENOUS LEUKEMIA; HEMATOPOIETIC-CELL TRANSPLANTATION; ACUTE PROMYELOCYTIC LEUKEMIA; COOPERATIVE-STUDY-GROUP; 2ND COMPLETE REMISSION; RANDOMIZED-TRIAL; ANTHRACYCLINE CARDIOTOXICITY; LIPOSOMAL DAUNORUBICIN; GEMTUZUMAB OZOGAMICIN;

D O I：

10.1111/bjh.12947

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognosis of paediatric acute myeloid leukaemia (AML) has improved significantly over the recent decades, but still about one-third of patients relapse. These patients have a relatively poor prognosis, with a probability of long-term survival from relapse of about 35%. This can only be achieved with very intensive chemotherapy and, usually, allogeneic stem cell transplantation, leading to very significant toxicity and even treatment-related mortality. Major improvements in the treatment of paediatric relapsed AML thus are required still, and several possibilities are discussed. In case of a suspected relapse, a comprehensive diagnostic work-up has to be undertaken, because significant changes in the biological features of the AML cells may have occurred between initial diagnosis and relapse. This review discusses many practical issues that one encounters in the treatment of children with relapsed AML. It will also be of interest for those involved in translational research in AML.

引用

页码：636 / 645

页数：10

共 63 条

[1] Improved outcome after relapse in children with acute myeloid leukaemia [J].

Abrahamsson, Jonas ;

Clausen, Niels ;

Gustafsson, Goran ;

Hovi, Liisa ;

Jonmundsson, Gudmundur ;

Zeller, Bernward ;

Forestier, Erik ;

Heldrup, Jesper ;

Hasle, Henrik .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 136 (02) :229-236

[2] Response-Guided Induction Therapy in Pediatric Acute Myeloid Leukemia With Excellent Remission Rate [J].

Abrahamsson, Jonas ;

Forestier, Erik ;

Heldrup, Jesper ;

Jahnukainen, Kirsi ;

Jonsson, Olafur G. ;

Lausen, Birgitte ;

Palle, Josefine ;

Zeller, Bernward ;

Hasle, Henrik .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (03) :310-315

[3] Outcome in children with relapsed acute myeloid leukemia after initial treatment with the French Leucemie Aique Myeloide Enfant (LAME) 89/91 protocol of the French Society of Pediatric Hematology and Immunology [J].

Aladjidi, N ;

Auvrignon, A ;

Leblanc, T ;

Perel, Y ;

Bénard, A ;

Bordigoni, P ;

Gandemer, V ;

Thuret, I ;

Dalle, JH ;

Piguet, C ;

Pautard, B ;

Baruchel, A ;

Leverger, G .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (23) :4377-4385

[4] The role of minor subpopulations within the leukemic blast compartment of AML patients at initial diagnosis in the development of relapse [J].

Bachas, C. ;

Schuurhuis, G. J. ;

Assaraf, Y. G. ;

Kwidama, Z. J. ;

Kelder, A. ;

Wouters, F. ;

Snel, A. N. ;

Kaspers, G. J. L. ;

Cloos, J. .

LEUKEMIA, 2012, 26 (06) :1313-1320

[5] High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine [J].

Bachas, Costa ;

Schuurhuis, Gerrit Jan ;

Hollink, Iris H. I. M. ;

Kwidama, Zinia J. ;

Goemans, Bianca F. ;

Zwaan, C. Michel ;

van den Heuvel-Eibrink, Marry M. ;

de Bont, Eveline S. J. M. ;

Reinhardt, Dirk ;

Creutzig, Ursula ;

de Haas, Valerie ;

Assaraf, Yehuda G. ;

Kaspers, Gertjan J. L. ;

Cloos, Jacqueline .

BLOOD, 2010, 116 (15) :2752-2758

[6] Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study [J].

Balgobind, Brian V. ;

Raimondi, Susana C. ;

Harbott, Jochen ;

Zimmermann, Martin ;

Alonzo, Todd A. ;

Auvrignon, Anne ;

Beverloo, H. Berna ;

Chang, Myron ;

Creutzig, Ursula ;

Dworzak, Michael N. ;

Forestier, Erik ;

Gibson, Brenda ;

Hasle, Henrik ;

Harrison, Christine J. ;

Heerema, Nyla A. ;

Kaspers, Gertjan J. L. ;

Leszl, Anna ;

Litvinko, Nathalia ;

Lo Nigro, Luca ;

Morimoto, Akira ;

Perot, Christine ;

Pieters, Rob ;

Reinhardt, Dirk ;

Rubnitz, Jeffrey E. ;

Smith, Franklin O. ;

Stary, Jan ;

Stasevich, Irina ;

Strehl, Sabine ;

Taga, Takashi ;

Tomizawa, Daisuke ;

Webb, David ;

Zemanova, Zuzana ;

Zwaan, C. Michel ;

van den Heuvel-Eibrink, Marry M. .

BLOOD, 2009, 114 (12) :2489-2496

[7] Allo-SCT using BU, CY and melphalan for children with AML in second CR [J].

Beier, R. ;

Albert, M. H. ;

Bader, P. ;

Borkhardt, A. ;

Creutzig, U. ;

Eyrich, M. ;

Ehlert, K. ;

Gruhn, B. ;

Greil, J. ;

Handgretinger, R. ;

Holter, W. ;

Klingebiel, T. ;

Kremens, B. ;

Lang, P. ;

Mauz-Koerholz, C. ;

Meisel, R. ;

Mueller, I. ;

Peters, C. ;

Reinhardt, D. ;

Sedlacek, P. ;

Schulz, A. ;

Schuster, F. R. ;

Schrauder, A. ;

Strahm, B. ;

Sykora, K. W. ;

Woessmann, W. ;

Zimmermann, M. ;

Sauer, M. G. .

BONE MARROW TRANSPLANTATION, 2013, 48 (05) :651-656

[8] Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia [J].

Buaboonnam, Jassada ;

Cao, Xueyuan ;

Pauley, Jennifer L. ;

Pui, Ching-Hon ;

Ribeiro, Raul C. ;

Rubnitz, Jeffrey E. ;

Inaba, Hiroto .

PEDIATRIC BLOOD & CANCER, 2013, 60 (07) :1161-1164

[9] Curability of Patients With Acute Myeloid Leukemia Who Did Not Undergo Transplantation in First Remission [J].

Burnett, Alan K. ;

Goldstone, Anthony ;

Hills, Robert K. ;

Milligan, Donald ;

Prentice, Archie ;

Yin, John ;

Wheatley, Keith ;

Hunter, Ann ;

Russell, Nigel .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (10) :1293-1301

[10] Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples [J].

Cloos, J. ;

Goemans, B. F. ;

Hess, C. J. ;

van Oostveen, J. W. ;

Waisfisz, Q. ;

Corthals, S. ;

de lange, D. ;

Boeckx, N. ;

Hahlen, K. ;

Reinhardt, D. ;

Creutzig, U. ;

Schuurhuis, G. J. ;

Zwaan, Ch M. ;

Kaspers, G. J. L. .

LEUKEMIA, 2006, 20 (07) :1217-1220

← 1 2 3 4 5 6 7 →