Cu-Catalyzed Arylcarbocyclization of Alkynes with Diaryliodonium Salts through C-C Bond Formation on Inert C(sp3)-H Bond

被引：57

作者：

Peng, Jing ^{[1
]}

Chen, Chao ^{[1
]}

Chen, Junjie ^{[1
]}

Su, Xiang ^{[1
]}

Xi, Chanjuan ^{[1
]}

Chen, Hui ^{[2
]}

机构：

[1] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 14期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; 2+2+2 CASCADE ANNULATION; H BOND; QUINAZOLINE DERIVATIVES; ALPHA-ARYLATION; ACTIVATION; CYCLIZATION; SECONDARY; INSERTION; ADJACENT;

D O I：

10.1021/ol501655g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed arylcarbocyclization reaction of alkynes was realized with diaryliodonium salts through C-C bond formation on an inert C-(sp3)-H bond. This method provides an efficient cyclization of alkyl alkynes to generate carbocycles with good step-economy. Theoretical study revealed an interesting Cu-catalyzed concerted pathway of the C-C bond formation.

引用

页码：3776 / 3779

页数：4

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