Synthesis, Toxicity, and Antituberculosis Activity of Isoniazid Derivatives Containing Sterically Hindered Phenols

被引：9

作者：

Oludina, Yu. N. ^{[1
]}

Voloshina, A. D. ^{[2
]}

Kulik, M. V. ^{[2
]}

Zobov, V. V. ^{[2
]}

Bukharov, S. V. ^{[1
]}

Tagasheva, R. G. ^{[1
]}

Nugumanova, G. N. ^{[1
]}

Burilov, A. R. ^{[2
]}

Kravchenko, M. A. ^{[3
]}

Skornyakov, S. N. ^{[3
]}

Rusinov, G. L. ^{[4
]}

机构：

[1] Kazan Natl Res Technol Univ, Kazan 420015, Tatarstan, Russia

[2] Russian Acad Sci, AE Arbuzov Organ & Phys Chem Inst, Kazan Sci Ctr, Kazan 420088, Tatarstan, Russia

[3] Minist Russian Federat Publ Hlth, Phthisiopulmonol Res Inst, Ekaterinburg 620039, Russia

[4] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, Ekaterinburg 620219, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

hybrid structures; sterically hindered phenols; isoniazid; acute toxicity; tuberculostatic activity;

D O I：

10.1007/s11094-014-1032-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The toxicity and tuberculostatic activity of new isoniazid derivatives containing sterically hindered phenols were investigated. The investigated isoniazid derivatives exhibited lower activity and toxicity than isoniazid.

引用

页码：5 / 7

页数：3