Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions

被引：440

作者：

Biessels, Geert Jan ^{[1
]}

Strachan, Mark W. J. ^{[3
]}

Visseren, Frank L. J. ^{[2
]}

Kappelle, L. Jaap ^{[1
]}

Whitmer, Rachel A. ^{[4
]}

机构：

[1] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Vasc Med, Utrecht, Netherlands

[3] Western Gen Hosp, Metab Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[4] Kaiser Permanente Div Res, Oakland, CA USA

来源：

LANCET DIABETES & ENDOCRINOLOGY | 2014年 / 2卷 / 03期

关键词：

VASCULAR RISK-FACTORS; SMALL VESSEL DISEASE; ALZHEIMERS-DISEASE; OLDER PATIENTS; SEVERE HYPOGLYCEMIA; HYPOTHETICAL MODEL; METABOLIC SYNDROME; GLOBAL PREVALENCE; BRAIN; IMPAIRMENT;

D O I：

10.1016/S2213-8587(13)70088-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. In this Review we discuss trajectories from normal cognition to dementia in people with type 2 diabetes, and explore opportunities for treatment. Slight diabetes-associated cognitive decrements and dementia affect different age groups and show a different evolution. These cognitive entities should therefore not be regarded as a continuum, although their effects might be additive. Vascular damage is a key underlying process in both entities. Glucose-mediated processes and other metabolic disturbances might also have a role. No treatment has been established, but management of vascular risk factors and optimisation of glycaemic control could have therapeutic benefit. We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities.

引用

页码：246 / 255

页数：10

共 106 条

[51] Adiposity, hyperinsulinemia, diabetes and Alzheimer's disease - An epidemiological perspective [J].

Luchsinger, Jose Alejandro .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 585 (01) :119-129

[52] Diabetes, hyperglycaemia, and acute ischaemic stroke [J].

Luitse, Merel J. A. ;

Biessels, Geert Jan ;

Rutten, Guy E. H. M. ;

Kappelle, L. Jaap .

LANCET NEUROLOGY, 2012, 11 (03) :261-271

[53] Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study [J].

Maillard, Pauline ;

Seshadri, Sudha ;

Beiser, Alexa ;

Himali, Jayandra J. ;

Au, Rhoda ;

Fletcher, Evan ;

Carmichael, Owen ;

Wolf, Philip A. ;

DeCarli, Charles .

LANCET NEUROLOGY, 2012, 11 (12) :1039-1047

[54] Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes [J].

Manschot, S. M. ;

Biessels, G. J. ;

de Valk, H. ;

Algra, A. ;

Rutten, G. E. H. M. ;

van der Grond, J. ;

Kappelle, L. J. .

DIABETOLOGIA, 2007, 50 (11) :2388-2397

[55] Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes [J].

Manschot, SM ;

Brands, AMA ;

van der Grond, J ;

Kessels, RPC ;

Algra, A ;

Kappelle, LJ ;

Biessels, GJ .

DIABETES, 2006, 55 (04) :1106-1113

[56] Association Between Raised Inflammatory Markers and Cognitive Decline in Elderly People With Type 2 Diabetes The Edinburgh Type 2 Diabetes Study [J].

Marioni, Riccardo E. ;

Strachan, Mark W. J. ;

Reynolds, Rebecca M. ;

Lowe, Gordon D. O. ;

Mitchell, Rory J. ;

Fowkes, F. Gerry R. ;

Frier, Brian M. ;

Lee, Amanda J. ;

Butcher, Isabella ;

Rumley, Ann ;

Murray, Gordon D. ;

Deary, Ian J. ;

Price, Jackie F. .

DIABETES, 2010, 59 (03) :710-713

[57] A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II [J].

Matthews, Fiona E. ;

Arthur, Antony ;

Barnes, Linda E. ;

Bond, John ;

Jagger, Carol ;

Robinson, Louise ;

Brayne, Carol .

LANCET, 2013, 382 (9902) :1405-1412

[58] The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease [J].

McClean, Paula L. ;

Parthsarathy, Vadivel ;

Faivre, Emilie ;

Hoelscher, Christian .

JOURNAL OF NEUROSCIENCE, 2011, 31 (17) :6587-6594

[59] Metabolic Syndrome and 16-Year Cognitive Decline in Community-Dwelling Older Adults [J].

McEvoy, Linda K. ;

Laughlin, Gail A. ;

Barrett-Connor, Elizabeth ;

Bergstrom, Jaclyn ;

Kritz-Silverstein, Donna ;

Der-Martirosian, Claudia ;

von Muehlen, Denise .

ANNALS OF EPIDEMIOLOGY, 2012, 22 (05) :310-317

[60] Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes [J].

Musen, Gail ;

Jacobson, Alan M. ;

Bolo, Nicolas R. ;

Simonson, Donald C. ;

Shenton, Martha E. ;

McCartney, Richard L. ;

Flores, Veronica L. ;

Hoogenboom, Wouter S. .

DIABETES, 2012, 61 (09) :2375-2379

← 1 2 3 4 5 6 7 8 9 10 →