Inhibition of nuclear factor-κB activation by 2′,8"-biapigenin

被引：34

作者：

Woo, Eun-Rhan ^{[1
]}

Pokharel, Yuba Raj ^{[1
]}

Yang, Jin Won ^{[1
]}

Lee, Song Yi ^{[1
]}

Kang, Keon Wook ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 05期

关键词：

2; 8; ''-biapigenin; cyclooxygenase (COX)-2; inhibitor-kappa B alpha; inducible nitric oxide synthase (iNOS); nuclear factor (NF)-kappa B; Selaginella tamariscina;

D O I：

10.1248/bpb.29.976

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an oriental medicine, which has been reported to inhibit the production of proinflammatory cytokines and cause cell cycle arrest. We isolated 2',8"-biapigenin from S. tamariscina and investigated whether it modulates iNOS and COX-2 expressions in Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). We found that 2',8"-biapigenin blocked the transactivations of iNOS and COX-2 genes via the inactivation of nuclear factor-kappa B by preventing the nuclear translocation of p65. Hence, it may be possible to develop S. tamariscina extracts or 2',8"-biapigenin as a useful agent for cancer chemoprevention or for the treatment of inflammatory diseases.

引用

页码：976 / 980

页数：5