Inhibition of nuclear factor-κB activation by 2′,8"-biapigenin

被引：34

作者：

Woo, Eun-Rhan ^{[1
]}

Pokharel, Yuba Raj ^{[1
]}

Yang, Jin Won ^{[1
]}

Lee, Song Yi ^{[1
]}

Kang, Keon Wook ^{[1
]}

机构：

[1] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2006年 / 29卷 / 05期

关键词：

2; 8; ''-biapigenin; cyclooxygenase (COX)-2; inhibitor-kappa B alpha; inducible nitric oxide synthase (iNOS); nuclear factor (NF)-kappa B; Selaginella tamariscina;

D O I：

10.1248/bpb.29.976

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an oriental medicine, which has been reported to inhibit the production of proinflammatory cytokines and cause cell cycle arrest. We isolated 2',8"-biapigenin from S. tamariscina and investigated whether it modulates iNOS and COX-2 expressions in Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). We found that 2',8"-biapigenin blocked the transactivations of iNOS and COX-2 genes via the inactivation of nuclear factor-kappa B by preventing the nuclear translocation of p65. Hence, it may be possible to develop S. tamariscina extracts or 2',8"-biapigenin as a useful agent for cancer chemoprevention or for the treatment of inflammatory diseases.

引用

页码：976 / 980

页数：5

共 31 条

[1] Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer [J].

Ambs, S ;

Bennett, WP ;

Merriam, WG ;

Ogunfusika, MO ;

Oser, SM ;

Harrington, AM ;

Shields, PG ;

Felley-Bosco, E ;

Hussain, SP ;

Harris, CC .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (01) :86-88

[2] NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle [J].

Brar, SS ;

Kennedy, TP ;

Sturrock, AB ;

Huecksteadt, TP ;

Quinn, MT ;

Murphy, TM ;

Chitano, P ;

Hoidal, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 282 (04) :L782-L795

[3] Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate [J].

Chung, FL ;

Conaway, CC ;

Rao, CV ;

Reddy, BS .

CARCINOGENESIS, 2000, 21 (12) :2287-2291

[4] Antioxidant activity of polyphenols from Hypericum triquetrifolium Turra [J].

Couladis, M ;

Baziou, P ;

Verykokidou, E ;

Loukis, A .

PHYTOTHERAPY RESEARCH, 2002, 16 (08) :769-770

[5] Evidence for common mechanisms in the transcriptional control of type II nitric oxide synthase in isolated hepatocytes - Requirement of NF-kappa B activation after stimulation with bacterial cell wall products and phorbol esters [J].

DiazGuerra, MJM ;

Velasco, M ;

MartinSanz, P ;

Bosca, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (47) :30114-30120

[6] Inflammation and the development of pancreatic cancer [J].

Farrow, B ;

Evers, BM .

SURGICAL ONCOLOGY-OXFORD, 2002, 10 (04) :153-169

[7] Intracellular oxidation reduction status in the regulation of transcription factors NF-κB and AP-1 [J].

Gius, D ;

Botero, A ;

Shah, S ;

Curry, HA .

TOXICOLOGY LETTERS, 1999, 106 (2-3) :93-106

[8] LPS induction of gene expression in human monocytes [J].

Guha, M ;

Mackman, N .

CELLULAR SIGNALLING, 2001, 13 (02) :85-94

[9]

HUGUET AI, 1990, Z NATURFORSCH C, V45, P19

[10] Thrombin induces nitric-oxide synthase via Gα12/13-coupled protein kinase C-dependent I-κBα phosphorylation and JNK-mediated I-κBα degradation [J].

Kang, KW ;

Choi, SY ;

Cho, MK ;

Lee, CH ;

Kim, SG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17368-17378

← 1 2 3 4 →