Top-down modulation of olfactory-guided behaviours by the anterior olfactory nucleus pars medialis and ventral hippocampus

被引：40

作者：

Aqrabawi, Afif J. ^{[1
]}

Browne, Caleb J. ^{[2
]}

Dargaei, Zahra ^{[1
]}

Garand, Danielle ^{[1
]}

Khademullah, C. Sahara ^{[1
]}

Woodin, Melanie A. ^{[1
]}

Kim, Jun Chul ^{[1
,2
]}

机构：

[1] Univ Toronto, Dept Cell & Syst Biol, 25 Harbord St, Toronto, ON M5S 3G5, Canada

[2] Univ Toronto, Dept Psychol, 100 St George St, Toronto, ON M5S 3G3, Canada

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

ODOR DISCRIMINATION; PIRIFORM CORTEX; BULB; RAT; SYSTEM; MICE; MAIN; ORGANIZATION; PROJECTIONS; SPECIALIZATION;

D O I：

10.1038/ncomms13721

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Olfactory processing is thought to be actively modulated by the top-down input from cortical regions, but the behavioural function of these signals remains unclear. Here we find that cortical feedback from the anterior olfactory nucleus pars medialis (mAON) bidirectionally modulates olfactory sensitivity and olfaction-dependent behaviours. To identify a limbic input that tunes this mAON switch, we further demonstrate that optogenetic stimulation of ventral hippocampal inputs to the mAON is sufficient to alter olfaction-dependent behaviours.

引用

页数：9

共 29 条

[1] Synaptic Inhibition in the Olfactory Bulb Accelerates Odor Discrimination in Mice [J].

Abraham, Nixon M. ;

Egger, Veronica ;

Shimshek, Derya R. ;

Renden, Robert ;

Fukunaga, Izumi ;

Sprengel, Rolf ;

Seeburg, Peter H. ;

Klugmann, Matthias ;

Margrie, Troy W. ;

Schaefer, Andreas T. ;

Kuner, Thomas .

NEURON, 2010, 65 (03) :399-411

[2] Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand [J].

Armbruster, Blaine N. ;

Li, Xiang ;

Pausch, Mark H. ;

Herlitze, Stefan ;

Roth, Bryan L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5163-5168

[3] Broadcasting of Cortical Activity to the Olfactory Bulb [J].

Boyd, Alison M. ;

Kato, Hiroyuki K. ;

Komiyama, Takaki ;

Isaacson, Jeffry S. .

CELL REPORTS, 2015, 10 (07) :1032-1039

[4] A field guide to the anterior olfactory nucleus (cortex) [J].

Brunjes, PC ;

Illig, KR ;

Meyer, EA .

BRAIN RESEARCH REVIEWS, 2005, 50 (02) :305-335

[5] QUANTITATIVE LOCALIZATION OF NEURONS PROJECTING TO THE MOUSE MAIN OLFACTORY-BULB [J].

CARSON, KA .

BRAIN RESEARCH BULLETIN, 1984, 12 (06) :629-634

[6]

Crawley J. N., 2011, CURRENT PROTOCOLS NE

[7] THE ORGANIZATION OF CENTRIFUGAL PROJECTIONS FROM THE ANTERIOR OLFACTORY NUCLEUS, VENTRAL HIPPOCAMPAL RUDIMENT, AND PIRIFORM CORTEX TO THE MAIN OLFACTORY-BULB IN THE HAMSTER - AN AUTORADIOGRAPHIC STUDY [J].

DAVIS, BJ ;

MACRIDES, F .

JOURNAL OF COMPARATIVE NEUROLOGY, 1981, 203 (03) :475-493

[8] AFFERENT CONNECTIONS OF MAIN AND ACCESSORY OLFACTORY-BULB FORMATIONS IN RAT - EXPERIMENTAL HRP-STUDY [J].

DEOLMOS, J ;

HARDY, H ;

HEIMER, L .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 181 (02) :213-244

[9] Temporal Processing in the Olfactory System: Can We See a Smell? [J].

Gire, David H. ;

Restrepo, Diego ;

Sejnowski, Terrence J. ;

Greer, Charles ;

De Carlos, Juan A. ;

Lopez-Mascaraque, Laura .

NEURON, 2013, 78 (03) :416-432

[10] Neuronal pattern separation in the olfactory bulb improves odor discrimination learning [J].

Gschwend, Olivier ;

Abraham, Nixon M. ;

Lagier, Samuel ;

Begnaud, Frederic ;

Rodriguez, Ivan ;

Carleton, Alan .

NATURE NEUROSCIENCE, 2015, 18 (10) :1474-+

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