Risk factors and biomarkers of severe dengue

被引：38

作者：

Rathore, Abhay P. S. ^{[1
]}

Farouk, Farouk S. ^{[2
]}

St John, Ashley L. ^{[1
,3
,4
,5
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[2] Duke Univ, Grad Program Global Hlth, Durham, NC USA

[3] Duke Natl Univ Singapore, Program Emerging Infect Dis, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore

[5] SingHlth Duke NUS Global Hlth Inst, Singapore, Singapore

来源：

CURRENT OPINION IN VIROLOGY | 2020年 / 43卷

基金：

新加坡国家研究基金会;

关键词：

NECROSIS-FACTOR-ALPHA; MAST-CELL TRYPTASE; HEMORRHAGIC-FEVER; VIRUS-INFECTION; SHOCK SYNDROME; ENDOTHELIAL GLYCOCALYX; GENE POLYMORPHISMS; DISEASE SEVERITY; PLASMA LEAKAGE; SERUM-LEVELS;

D O I：

10.1016/j.coviro.2020.06.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue virus infects several million people each year. Although usually a self-limiting disease, some patients can develop life-threatening severe complications, characterized by plasma leakage, hemorrhaging, and shock. The signs and symptoms of severe disease usually arise late in the disease course when patients are recovering and fever has subsided, making it difficult to predict. Efforts are underway to identify risk factors and biomarkers that can accurately predict disease severity in the acute febrile phase of the disease, facilitating early intervention and treatment strategies for those at greatest risk. In this review we discuss recent advancements in identifying risk factors and biomarkers for the prognosis of severe dengue.

引用

页码：1 / 8

页数：8

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