CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-α

被引：35

作者：

Guo, Xiaohuan ^{[1
]}

Li, Ting ^{[1
]}

Wang, Yu ^{[1
]}

Shao, Luning ^{[1
]}

Zhang, Yingmei ^{[1
]}

Ma, Dalong ^{[1
]}

Han, Wenling ^{[1
]}

机构：

[1] Peking Univ, Sch Basic Med Sci, Ctr Human Dis Genom, Dept Immunol, Beijing 100191, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 387卷 / 01期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

CMTM5; Pancreatic cancer; Apoptosis; TNF-alpha; CLONING;

D O I：

10.1016/j.bbrc.2009.06.148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our previous data show that CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) is a potential tumor suppressor gene, but its function ill pancreatic cancer is Unknown. Herein we first report that CMTM5 is also absent in pancreatic cancer cell lines with promoter methylation. Compared with normal pancreatic tissues, CMTM5 is significantly decreased in cancer tissues. Restoration of CMTM5-v1 not only induces MIA PaCa-2 cell apoptosis with activation of caspase 3, 8 and 9. but also has synergistic effects with TNF-alpha. Thus, CMTM5 may play a role in the pancreatic cancer. (C) 2009 Elsevier Inc. All results reserved.

引用

收藏

页码：139 / 142

页数：4

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