Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

被引:211
作者
Josse, Jerome [1 ]
Velard, Frederic [1 ]
Gangloff, Sophie C. [1 ]
机构
[1] Univ Reims, Pole Sante, EA Biomat & Inflammat Site Osseux 4691, Reims, France
关键词
Staphylococcus aureus; osteoblast; internalization; inflammation; antibiotics; antimicrobial peptide; phenol soluble modulin; small colony variants; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PATTERN-RECOGNITION RECEPTORS; FIBRONECTIN-BINDING PROTEINS; ANTIMICROBIAL PEPTIDE LL-37; COLLAGEN ADHESIN GENE; NECROSIS-FACTOR-ALPHA; SMALL COLONY VARIANTS; FACTOR-KAPPA-B; BONE SIALOPROTEIN; OSTEOCLAST DIFFERENTIATION;
D O I
10.3389/fcimb.2015.00085
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bone cells, namely osteoblasts and osteoclasts work in concert and are responsible for bone extracellular matrix formation and resorption. This homeostasis is, in part, altered during infections by Staphylococcus aureus through the induction of various responses from the osteoblasts. This includes the over production of chemokines, cytokines and growth factors, thus suggesting a role for these cells in both innate and adaptive immunity. S. aureus decreases the activity and viability of osteoblasts, by induction of apoptosis-dependent and independent mechanisms. The tight relationship between osteoclasts and osteoblasts is also modulated by S. aureus infection. The present review provides a survey of the relevant literature discussing the important aspects of S. aureus and osteoblast interaction as well as the ability for antimicrobial peptides to kill intra-osteoblastic S. aureus, hence emphasizing the necessity for new anti-infectious therapeutics.
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页数:17
相关论文
共 132 条
[1]   Staphylococcus aureus fibronectin binding proteins are essential for internalization by osteoblasts but do not account for differences in intracellular levels of bacteria [J].
Ahmed, S ;
Meghji, S ;
Williams, RJ ;
Henderson, B ;
Brock, JH ;
Nair, SP .
INFECTION AND IMMUNITY, 2001, 69 (05) :2872-2877
[2]   Staphylococcus aureus-induced tumor necrosis factor-related apoptosis-inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts -: art. no. 5 [J].
Alexander, EH ;
Rivera, FA ;
Marriott, I ;
Anguita, J ;
Bost, KL ;
Hudson, MC .
BMC MICROBIOLOGY, 2003, 3 (1) :1-11
[3]   Staphylococcus aureus and Salmonella enterica serovar Dublin induce tumor necrosis factor-related apoptosis-inducing ligand expression by normal mouse and human osteoblasts [J].
Alexander, EH ;
Bento, JL ;
Hughes, FM ;
Marriott, I ;
Hudson, MC ;
Bost, KL .
INFECTION AND IMMUNITY, 2001, 69 (03) :1581-1586
[4]   Prevalence of Adhesion and Regulation of Biofilm-Related Genes in Different Clones of Staphylococcus aureus [J].
Atshan, Salman Sahab ;
Shamsudin, Mariana Nor ;
Sekawi, Zamberi ;
Lung, Leslie Than Thian ;
Hamat, Rukman Awang ;
Karunanidhi, Arunkumar ;
Ali, Alreshidi Mateg ;
Ghaznavi-Rad, Ehsanollah ;
Ghasemzadeh-Moghaddam, Hamed ;
Seng, Johnson Shueh Chong ;
Nathan, Jayakayatri Jeevajothi ;
Pei, Chong Pei .
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,
[5]   Internalization of bacteria by osteoblasts in a patient with recurrent, long-term osteomyelitis - A case report [J].
Bosse, MJ ;
Gruber, HE ;
Ramp, WK .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (06) :1343-1347
[6]   Streptococcus aureus infection of mouse or human osteoblasts induces high levels of interleukin-6 and interleukin-12 production [J].
Bost, KL ;
Ramp, WK ;
Nicholson, NC ;
Bento, JL ;
Marriott, I ;
Hudson, MC .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :1912-1920
[7]   Induction of colony-stimulating factor expression following Staphylococcus or Salmonella interaction with mouse or human osteoblasts [J].
Bost, KL ;
Bento, JL ;
Ellington, JK ;
Marriott, I ;
Hudson, MC .
INFECTION AND IMMUNITY, 2000, 68 (09) :5075-5083
[8]   Monocyte chemoattractant protein-1 expression by osteoblasts following infection with Staphylococcus aureus or Salmonella [J].
Bost, KL ;
Bento, JL ;
Petty, CC ;
Schrum, LW ;
Hudson, MC ;
Marriott, I .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2001, 21 (05) :297-304
[9]   Osteoclast differentiation and activation [J].
Boyle, WJ ;
Simonet, WS ;
Lacey, DL .
NATURE, 2003, 423 (6937) :337-342
[10]   The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic implant infections [J].
Campoccia, Davide ;
Speziale, Pietro ;
Ravaioli, Stefano ;
Cangini, Ilaria ;
Rindi, Simonetta ;
Pirini, Valter ;
Montanaro, Lucio ;
Arciola, Carla Renata .
BIOMATERIALS, 2009, 30 (34) :6621-6628