Orexin-A controls sympathetic activity and eating behavior

被引：92

作者：

Messina, Giovanni ^{[1
]}

Dalia, Carmine ^{[1
]}

Tafuri, Domenico ^{[2
]}

Monda, Vincenzo ^{[1
]}

Palmieri, Filomena ^{[1
]}

Dato, Amelia ^{[1
]}

Russo, Angelo ^{[1
]}

De Blasio, Saverio ^{[1
]}

Messina, Antonietta ^{[1
]}

De Luca, Vincenzo ^{[3
]}

Chieffi, Sergio ^{[1
]}

Monda, Marcellino ^{[1
]}

机构：

[1] Univ Naples 2, Dept Expt Med, Sect Human Physiol & Clin Dietet Serv, I-80138 Naples, Italy

[2] Parthenope Univ Naples, Fac Motor Sci, Naples, Italy

[3] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

来源：

FRONTIERS IN PSYCHOLOGY | 2014年 / 5卷

关键词：

body weight; orexin-A; energy expenditure; sympathetic nervous system; behavior; ADIPOSE-TISSUE THERMOGENESIS; RECEPTOR MESSENGER-RNA; HYPERTHERMIC REACTIONS; NERVOUS-SYSTEM; BODY-WEIGHT; ECONOMIC CONSEQUENCES; ENERGY HOMEOSTASIS; HYPOCRETIN NEURONS; PERIPHERAL-TISSUES; CEREBRAL INJECTION;

D O I：

10.3389/fpsyg.2014.00997

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

It is extremely important for the health to understand the regulatory mechanisms of energy expenditure. These regulatory mechanisms play a central role in the pathogenesis of body weight alteration. The hypothalamus integrates nutritional information derived from all peripheral organs. This region of the brain controls hormonal secretions and neural pathways of the brainstem. Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is involved in the control of the sympathetic activation, blood pressure, metabolic status, and blood glucose level. This minireview focuses on relationship between the sympathetic nervous system and orexin-A in the control of eating behavior and energy expenditure. The "thermoregulatory hypothesis" of food intake is analyzed, underlining the role played by orexin-A in the control of food intake related to body temperature. Furthermore, the paradoxical eating behavior induced orexin-A is illustrated in this minireview.

引用

页数：7

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