Bioavailability of glucosyl hesperidin in rats

被引：123

作者：

Yamada, Mika ^{[1
]}

Tanabe, Fujimi ^{[1
]}

Arai, Norie ^{[1
]}

Mitsuzumi, Hitoshi ^{[1
]}

Miwa, Yoshikatsu ^{[1
]}

Kubota, Michio ^{[1
]}

Chaen, Hiroto ^{[1
]}

Kibata, Masayoshi ^{[1
]}

机构：

[1] Hayashibara Biochem Labs Inc, Okayama 7000907, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 06期

关键词：

hesperidin; glucosyl hesperidin; hesperetin conjugates; intestinal bacteria; bioavailability;

D O I：

10.1271/bbb.50657

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucosyl hesperidin (G-hesperidin) is a water-soluble derivative of hesperidin. We compared the absorption and metabolism of G-hesperidin with those of hesperidin in rats. After oral administration of G-hesperidin or hesperidin to rats, hesperetin was detected in sera hydrolyzed with beta-glucuronidase, but it was not detectable in unhydrolyzed sera. Serum hesperetin was found more rapidly in rats administered G-hesperidin than in those administered hesperidin. The area under the concentration-time curve for hesperetin in the sera of rats administered G-hesperidin was approximately 3.7-fold greater than that of rats administered hesperidin. In the urine of both administration groups, hesperetin and its glucuronide were found. Urinary excretion of metabolites was higher in rats administered G-hesperidin than in those administered hesperidin. These results indicate that G-hesperidin presents the same metabolic profile as hesperidin. Moreover, it was concluded that G-hesperidin is absorbed more rapidly and efficiently than hesperidin, because of its high water solubility.

引用

页码：1386 / 1394

页数：9

共 32 条

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