CENP-A nucleosome-a chromatin-embedded pedestal for the centromere: lessons learned from structural biology

被引：15

作者：

Ali-Ahmad, Ahmad ^{[1
]}

Sekulic, Nikolina ^{[1
,2
]}

机构：

[1] Univ Oslo, Fac Med, Nord EMBL Partnership, Ctr Mol Med Norway NCMM, N-0318 Oslo, Norway

[2] Univ Oslo, Dept Chem, POB 1033, NO-0315 Blindern, Norway

来源：

KINETOCHORES AND CHROMOSOME SEGREGATION | 2020年 / 64卷 / 02期

关键词：

B NULL MICE; CRYSTAL-STRUCTURE; CORE PARTICLE; CRYO-EM; HISTONE OCTAMER; PROTEIN-DNA; IN-VITRO; RECOGNITION; COMPLEX; SEQUENCE;

D O I：

10.1042/EBC20190074

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, we summarize findings from recent structural biology studies, including several CryoEM structures, that contributed to elucidate specific features of the CENP-A nucleosome and molecular determinants of its interactions with CENP-C and CENP-N, the only two centromere proteins that directly bind to it. Based on those findings, we propose a role of the CENP-A nucleosome in the organization of centromeric chromatin beyond binding centromeric proteins.

引用

页码：205 / 221

页数：17

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