Hydrogels as Carriers for Stem Cell Transplantation

被引：25

作者：

Alvarado-Velez, Melissa ^{[1
]}

Pai, S. Balakrishna ^{[1
]}

Bellamkonda, Ravi V. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Neurol Biomat & Canc Therapeut Lab, Wallace H Coulter Dept Biomed Engn,Georgia Inst T, Atlanta, GA 30332 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2014年 / 61卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Immunomodulation; injectable hydrogels; stem cell transplantation; RESPONSIVE CHITOSAN HYDROGEL; IN-VITRO; CHONDROGENIC DIFFERENTIATION; IMMUNE PRIVILEGE; GROWTH-FACTOR; CARDIOMYOCYTE DIFFERENTIATION; PHOTOPOLYMERIZABLE HYDROGEL; NEURONAL DIFFERENTIATION; SKELETAL-MUSCLE; SCAFFOLDS;

D O I：

10.1109/TBME.2014.2305753

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Stem cells are a promising source for cell replacement therapy for several degenerative conditions. However, a number of limitations such as low cell survival, uncontrolled and/or low differentiation, induction of host immune response, and the risk of teratoma formation remain as challenges. In this review, we explore the utility of hydrogels as carriers for stem cell delivery and their potential to overcome some of the current limitations in stem cell therapy. We focus on in situ gelling hydrogels, and also discuss other strategies to modulate the immune response to promote controlled stem cell differentiation. Immunomodulatory hydrogels and gels designed to promote cell survival and integration into the host site will likely have a significant effect on enhancing the efficacy of stem cell transplantation as a therapy for debilitating degenerative diseases.

引用

页码：1474 / 1481

页数：8

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