The efficacy assessments of alkylating drugs induced by nano-Fe3O4/CA for curing breast and hepatic cancer

被引：23
作者：
He, Kui [1 ]
Ma, Ying [1 ,2 ]
Yang, Bin [1 ]
Liang, Caishuang [1 ]
Chen, Xiaoming [1 ]
Cai, Changqun [1 ]
机构：
[1] Xiangtan Univ, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China
[2] Avic Aviat Powerplant Res Inst, Zhuzhou 412002, Hunan, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2017年 / 173卷
基金：
中国国家自然科学基金;
关键词：
Resonance light scattering (RLS); Nano-Fe3O4; Anticancer drugs; Breast cancer; Cell apoptosis; RESONANCE LIGHT-SCATTERING; DNA-BINDING; NANOPARTICLES; THERAPY; MECHANISM; DELIVERY; CELLS;
D O I：
10.1016/j.saa.2016.08.047
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A new method to evaluate the anticancer activity at the molecular level has been developed. In our assay, the interaction between alkylating anticancer drugs-Fe3O4/CA with DNA has been investigated for the Resonance Light Scattering (RLS) signal enhancement. Water-based nano-Fe3O4, as a probe, has the ability of good solubility, biodegradability and low bulk resistivity etc. The experimental results show that, the activity order of three kinds of drugs is Nimustine (ACNU) > Semustine (Me-CCNU) > Chlormethine (HN2), which is satisfied with the results of the cell apoptosis experiment and the IC50 by MU method. This assay is simple, sensitive and high efficient. And the theoretical basics for the development of new anticancer drugs as well as the assessments of their efficacy to cure breast and hepatic cancer have been provided. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：82 / 86
页数：5
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