In Situ Proteome Profiling of C75, a Covalent Bioactive Compound with Potential Anticancer Activities

被引：22

作者：

Cheng, Xiamin ^{[1
]}

Li, Lin ^{[1
]}

Uttamchandani, Mahesh ^{[1
,2
]}

Yao, Shao Q. ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] DSO Natl Labs, Def Med & Environm Res Inst, Singapore 117510, Singapore

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 05期

基金：

英国医学研究理事会;

关键词：

FATTY-ACID SYNTHASE; INHIBITOR; MECHANISM; DESIGN; KINASE;

D O I：

10.1021/ol500206w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A library of cell-permeable, minimally tagged C75 analogues was synthesized and used to uncover biological targets in human liver cancer cells. Known targets of C75, namely FASN and CPT1A, together with other unknown targets, including PDIA3, TFRC, and GAPDH, were thus identified.

引用

页码：1414 / 1417

页数：4

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