The protective effect of persistent trigeminal artery in patients with ischemic stroke

Background: Almost all case reports related to persistent trigeminal artery indicated that the existence of persistent trigeminal artery may increase the risk of ischemic stroke. However our case demonstrated that the persistent trigeminal artery may also play a protective role in preventing severe ischemic stroke by functioning as collateral circulation. Case presentation: We reported a patient with left internal carotid artery occlusion with persistent trigeminal artery manifesting only as a minor acute ischemia stroke exhibiting acute onset of dizziness and difficulty in walking. Brain MRI showed two small areas of restricted diffusion on diffusion-weighted imaging in the left hemisphere. The digital subtraction angiography showed his left middle cerebral artery and bilateral anterior cerebral artery were supplied by the basilar artery via a persistent trigeminal artery. Furthermore, CT perfusion showed no remarkable difference between the two hemispheres. Conclusions: Persistent trigeminal artery may have a protective role in the setting of an acquired occlusion of homolateral internal carotid artery. Therefore, it is important to fully assess the presence of the persistent trigeminal artery in acute ischemic stroke.