Toward a wide-field retinal prosthesis

被引:35
作者
Ameri, Hossein [1 ]
Ratanapakorn, Tanapat [2 ]
Ufer, Stefan [3 ]
Eekhardt, Helmut [3 ]
Humayun, Mark S. [1 ]
Weiland, James D. [1 ]
机构
[1] Univ So Calif, Keck Sch Med, Doheny Eye Inst, Doheny Retina Inst, Los Angeles, CA 90033 USA
[2] Khon Kaen Univ, Fac Med, Dept Ophthalmol, Srinagarind Hosp, Khon Kaen, Thailand
[3] Premitec Inc, Raleigh, NC USA
关键词
INTRAOCULAR FOREIGN-BODIES; SALISBURY EYE EVALUATION; PIXELIZED VISION SYSTEM; RETINITIS-PIGMENTOSA; MOBILITY PERFORMANCE; ELECTRICAL-STIMULATION; MORPHOMETRIC-ANALYSIS; MACULAR DEGENERATION; VISUAL FUNCTION; IMPLANTATION;
D O I
10.1088/1741-2560/6/3/035002
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The purpose of this paper is to present a wide field electrode array that may increase the field of vision in patients implanted with a retinal prosthesis. Mobility is often impaired in patients with low vision, particularly in those with peripheral visual loss. Studies on low vision patients as well as simulation studies on normally sighted individuals have indicated a strong correlation between the visual field and mobility. In addition. it has been shown that an increased visual field is associated with a significant improvement in visual acuity and object discrimination. Current electrode arrays implanted in animals or human vary in sized however, the retinal area covered by the electrodes has a maximum projected visual field of about 10 degrees. We have designed wide field electrode arrays that could potentially provide a visual field of 34 degrees, which may significantly improve the mobility. Tests performed on a mechanical eye model showed that it was possible to fix 10 mm wide flexible polyimide dummy electrode arrays onto the retina using a single retinal tack. They also showed that the arrays could conform to the inner curvature of the eye. Surgeries on an enucleated porcine eye model demonstrated feasibility of implantation of 10 mm wide arrays through a 5 mm eye wall incision.
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页数:8
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