Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients: Results from the ColoCare Study

被引:36
作者
Himbert, Caroline [1 ,2 ]
Ose, Jennifer [1 ,2 ]
Lin, Tengda [1 ,2 ]
Warby, Christy A. [1 ,2 ]
Gigic, Biljana [3 ]
Steindorf, Karen [4 ,5 ]
Schrotz-King, Petra [5 ]
Abbenhardt-Martin, Clare [5 ]
Zielske, Lin [3 ]
Boehm, Juergen [1 ,2 ]
Ulrich, Cornelia M. [1 ,2 ]
机构
[1] Huntsman Canc Inst, 2000 Circle Hope Dr Room 4725, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA
[3] Univ Clin Heidelberg, Dept Surg, Heidelberg, Germany
[4] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany
[5] Natl Ctr Tumor Dis, Heidelberg, Germany
基金
美国国家卫生研究院;
关键词
angiogenesis; biomarker; colorectal cancer; fatigue; inflammation; QUALITY-OF-LIFE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOTHELIAL GROWTH-FACTOR; C-REACTIVE PROTEIN; RISK-FACTORS; PHASE-II; THERAPY; SLEEP; CHEMOTHERAPY; ASSOCIATIONS;
D O I
10.1111/ecc.13055
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNF alpha, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue.
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页数:10
相关论文
共 58 条
[1]   Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe [J].
Aggarwal, Bharat B. ;
Vijayalekshmi, R. V. ;
Sung, Bokyung .
CLINICAL CANCER RESEARCH, 2009, 15 (02) :425-430
[2]  
[Anonymous], 2001, EORTC QLQ-C30 Scoring Manual
[3]   Cancer survivors' adherence to lifestyle behavior recommendations and associations with health-related quality of life: Results from the American Cancer Society's SCS-II [J].
Blanchard, Christopher M. ;
Courneya, Kerry S. ;
Stein, Kevin .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (13) :2198-2204
[4]   Candidate Predictors of Health-Related Quality of Life of Colorectal Cancer Survivors: A Systematic Review [J].
Bours, Martijn J. L. ;
van der Linden, Bernadette W. A. ;
Winkels, Renate M. ;
van Duijnhoven, Franzel J. ;
Mols, Floortje ;
van Roekel, Eline H. ;
Kampman, Ellen ;
Beijer, Sandra ;
Weijenberg, Matty P. .
ONCOLOGIST, 2016, 21 (04) :433-452
[5]   Cancer-related fatigue-mechanisms, risk factors, and treatments [J].
Bower, Julienne E. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2014, 11 (10) :597-609
[6]   Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy [J].
Capuron, L ;
Ravaud, A ;
Dantzer, R .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (10) :2143-2151
[7]   Temporal reliability of cytokines and growth factors in EDTA plasma [J].
Clendenen T.V. ;
Arslan A.A. ;
Lokshin A.E. ;
Idahl A. ;
Hallmans G. ;
Koenig K.L. ;
Marrangoni A.M. ;
Nolen B.M. ;
Ohlson N. ;
Zeleniuch-Jacquotte A. ;
Lundin E. .
BMC Research Notes, 3 (1)
[8]   Inflammation and cancer [J].
Coussens, LM ;
Werb, Z .
NATURE, 2002, 420 (6917) :860-867
[9]   Twenty years of research on cytokine-induced sickness behavior [J].
Dantzer, Robert ;
Kelley, Keith W. .
BRAIN BEHAVIOR AND IMMUNITY, 2007, 21 (02) :153-160
[10]   Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery [J].
Doong, Sy-Huey ;
Dhruva, Anand ;
Dunn, Laura B. ;
West, Claudia ;
Paul, Steven M. ;
Cooper, Bruce A. ;
Elboim, Charles ;
Abrams, Gary ;
Merriman, John D. ;
Langford, Dale J. ;
Leutwyler, Heather ;
Baggott, Christina ;
Kober, Kord ;
Aouizerat, Bradley E. ;
Miaskowski, Christine .
BIOLOGICAL RESEARCH FOR NURSING, 2015, 17 (03) :237-247