Does Statin Usage Reduce the Risk of Corticosteroid-Related Osteonecrosis in Renal Transplant Population?

被引：81

作者：

Ajmal, Muhammad ^{[2
]}

Matas, A. J. ^{[3
]}

Kuskowski, Michael ^{[4
]}

Cheng, Edward Y. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55454 USA

[2] Vanderbilt Univ, Vet Affairs Hosp, Dept Orthopaed Surg, Nashville, TN 37212 USA

[3] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA

[4] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN 55417 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2009年 / 40卷 / 02期

关键词：

Osteonecrosis; Statins; Avascular necrosis; Transplant; Incidence; NONTRAUMATIC AVASCULAR NECROSIS; SYSTEMIC LUPUS-ERYTHEMATOSUS; STEROID-INDUCED ADIPOGENESIS; FEMORAL-HEAD; INTRAVASCULAR COAGULATION; BONE-MARROW; PATHOGENESIS; RECIPIENTS; THERAPY; COMPLICATIONS;

D O I：

10.1016/j.ocl.2009.01.004

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.

引用

页码：235 / +

页数：6

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