Treatment of Langerhans cell histiocytosis with 2 chlorodeoxyadenosine

被引：17

作者：

Dimopoulos, MA ^{[1
]}

Theodorakis, M ^{[1
]}

Kostis, E ^{[1
]}

Papadimitris, C ^{[1
]}

Moulopoulos, LA ^{[1
]}

AnastasiouNana, M ^{[1
]}

机构：

[1] UNIV ATHENS,SCH MED,ALEXANDRA HOSP,DEPT CLIN THERAPEUT,GR-11527 ATHENS,GREECE

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 25卷 / 1-2期

关键词：

2; chlorodeoxyadenosine; Langerhans cell histiocytosis; 2-CHLORODEOXYADENOSINE; TOXICITY; THERAPY;

D O I：

10.3109/10428199709042509

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Langerhans-cell histiocytosis (LCH) is a rare condition with a wide clinical spectrum and variable prognosis. Patients with multisystem LCH have been treated with a variety of agents but may develop resistant and progressive disease. Based on a preliminary encouraging report on the activity of 2 chlorodoxyadenosine in this disease, we administered this agent to a patient with LCH which was resistant to corticosteroids and etoposide. After 4 courses of treatment the patient achieved a complete remission which is currently ongoing for 12 months. 2 CdA appears to be effective in patients with resistant LCH and warrants investigation in previously untreated patients with poor risk disease.

引用

页码：187 / 189

页数：3

共 9 条

[1] POTENT TOXICITY OF 2-CHLORODEOXYADENOSINE TOWARD HUMAN MONOCYTES INVITRO AND INVIVO - A NOVEL-APPROACH TO IMMUNOSUPPRESSIVE THERAPY [J].

CARRERA, CJ ;

TERAI, C ;

LOTZ, M ;

CURD, JG ;

PIRO, LD ;

BEUTLER, E ;

CARSON, DA .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (05) :1480-1488

[2]

CLINE MJ, 1994, BLOOD, V84, P2840

[3] TREATMENT STRATEGY FOR DISSEMINATED LANGERHANS CELL HISTIOCYTOSIS [J].

GADNER, H ;

HEITGER, A ;

GROIS, N ;

GATTERERMENZ, I ;

LADISCH, S .

MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 23 (02) :72-80

[4]

KOMP DM, 1991, SEMIN ONCOL, V18, P18

[5]

MAHMOUD HH, 1991, BLOOD, V77, P721

[6] 2-CHLORODEOXYADENOSINE-INDUCED COMPLETE REMISSIONS IN LANGERHANS-CELL HISTIOCYTOSIS [J].

SAVEN, A ;

FOON, KA ;

PIRO, LD .

ANNALS OF INTERNAL MEDICINE, 1994, 121 (06) :430-432

[7] MECHANISM OF DEOXYADENOSINE AND 2-CHLORODEOXYADENOSINE TOXICITY TO NONDIVIDING HUMAN-LYMPHOCYTES [J].

SETO, S ;

CARRERA, CJ ;

KUBOTA, M ;

WASSON, DB ;

CARSON, DA .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (02) :377-383

[8]

TALLMAN MS, 1995, BLOOD, V86, P2463

[9] LANGERHANS-CELL HISTIOCYTOSIS (HISTIOCYTOSIS-X) - A CLONAL PROLIFERATIVE DISEASE [J].

WILLMAN, CL ;

BUSQUE, L ;

GRIFFITH, BB ;

FAVARA, BE ;

MCCLAIN, KL ;

DUNCAN, MH ;

GILLILAND, DG .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (03) :154-160

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