Dendritic cells during Epstein Barr virus infection

被引：19
作者：
Muenz, Christian [1 ]
机构：
[1] Univ Zurich, Inst Expt Immunol, CH-8057 Zurich, Switzerland
来源：
FRONTIERS IN MICROBIOLOGY | 2014年 / 5卷
基金：
瑞士国家科学基金会; 英国医学研究理事会; 英国惠康基金;
关键词：
plasmacytoid dendritic cells; conventional dendritic cells; monocyte-derived dendritic cells; natural killer cells; T cells; NATURAL-KILLER-CELLS; TRANSFORMED B-CELLS; NK CELLS; EBV; LYMPHOCYTES; MONOCYTES; RESPONSES; RECEPTOR; MONONUCLEOSIS; RECOGNITION;
D O I：
10.3389/fmicb.2014.00308
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This gamma-herpes virus infects primarily human B and epithelial cells,but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and initiate EBV-specific adaptive immune responses via cross-priming. The respective evidence and their potential importance for EBV-specific vaccine development will be discussed in this review.
引用
收藏
页数：5
相关论文
共 51 条
  • [21] Targeting the nuclear antigen I of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
    Gurer, Cagan
    Strowig, Till
    Brilot, Fabienne
    Pack, Maggi
    Trumpfheller, Christine
    Arrey, Frida
    Park, Chae Gyu
    Steinman, Ralph M.
    Munz, Christian
    [J]. BLOOD, 2008, 112 (04) : 1231 - 1239
  • [22] Cellular responses to viral infection in humans: Lessons from Epstein-Barr virus
    Hislop, Andrew D.
    Taylor, Graham S.
    Sauce, Delphine
    Rickinson, Alan B.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2007, 25 : 587 - 617
  • [23] Characteristics of Hodgkin's lymphoma after infectious mononucleosis
    Hjalgrim, H
    Askling, J
    Rostgaard, K
    Hamilton-Dutoit, S
    Frisch, M
    Zhang, J
    Madsen, M
    Rosdahl, N
    Konradsen, HB
    Storm, HH
    Melbye, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (14) : 1324 - 1332
  • [24] Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3
    Iwakiri, Dai
    Zhou, Li
    Samanta, Mrinal
    Matsumoto, Misako
    Ebihara, Takashi
    Seya, Tsukasa
    Imai, Shosuke
    Fujieda, Mikiya
    Kawa, Keisei
    Takada, Kenzo
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (10) : 2091 - 2099
  • [25] Toll-like receptor control of the adaptive immune responses
    Iwasaki, A
    Medzhitov, R
    [J]. NATURE IMMUNOLOGY, 2004, 5 (10) : 987 - 995
  • [26] Spectrum of Epstein-Barr virus-associated diseases
    Kutok, J. L.
    Wang, F.
    [J]. ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2006, 1 (01) : 375 - 404
  • [27] Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo
    Laichalk, LL
    Thorley-Lawson, DA
    [J]. JOURNAL OF VIROLOGY, 2005, 79 (02) : 1296 - 1307
  • [28] Infectious diseases in humanized mice
    Leung, Carol
    Chijioke, Obinna
    Gujer, Cornelia
    Chatterjee, Bithi
    Antsiferova, Olga
    Landtwing, Vanessa
    McHugh, Donal
    Raykova, Ana
    Muenz, Christian
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (09) : 2246 - 2254
  • [29] Robust T-cell stimulation by Epstein-Barr virus-transformed B cells after antigen targeting to DEC-205
    Leung, Carol S.
    Maurer, Michael A.
    Meixlsperger, Sonja
    Lippmann, Anne
    Cheong, Cheolho
    Zuo, Jianmin
    Haigh, Tracey A.
    Taylor, Graham S.
    Muenz, Christian
    [J]. BLOOD, 2013, 121 (09) : 1584 - 1594
  • [30] Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4
    Li, LQ
    Liu, DR
    Hutt-Fletcher, L
    Morgan, A
    Masucci, MG
    Levitsky, V
    [J]. BLOOD, 2002, 99 (10) : 3725 - 3734
123456