Dendritic cells during Epstein Barr virus infection

被引：19
作者：
Muenz, Christian [1 ]
机构：
[1] Univ Zurich, Inst Expt Immunol, CH-8057 Zurich, Switzerland
来源：
FRONTIERS IN MICROBIOLOGY | 2014年 / 5卷
基金：
瑞士国家科学基金会; 英国惠康基金; 英国医学研究理事会;
关键词：
plasmacytoid dendritic cells; conventional dendritic cells; monocyte-derived dendritic cells; natural killer cells; T cells; NATURAL-KILLER-CELLS; TRANSFORMED B-CELLS; NK CELLS; EBV; LYMPHOCYTES; MONOCYTES; RESPONSES; RECEPTOR; MONONUCLEOSIS; RECOGNITION;
D O I：
10.3389/fmicb.2014.00308
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This gamma-herpes virus infects primarily human B and epithelial cells,but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and initiate EBV-specific adaptive immune responses via cross-priming. The respective evidence and their potential importance for EBV-specific vaccine development will be discussed in this review.
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页数：5
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