Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2-a]pyrimidines

被引：61
作者：
Qian, Guangyin [1 ]
Liu, Bingxin [1 ]
Tan, Qitao [1 ]
Zhang, Siwen [1 ]
Xu, Bin [1 ,2 ,3 ]
机构：
[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[3] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 22期
基金：
中国国家自然科学基金;
关键词：
Synthetic methods; Nitrogen heterocycles; C-H functionalization; Amination; Iodine; N BOND FORMATION; C-H AMINATION; OXIDATIVE CYCLIZATION; EFFICIENT ACCESS; DERIVATIVES; ALKENES; ARENES; CYCLOAMINATION; INHIBITORS; REACTIVITY;
D O I：
10.1002/ejoc.201402456
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and mild synthesis of imidazo[1,2-a]pyrimidine derivatives has been developed from readily available pyrimidyl arylamines or enamines through a hypervalent iodine-promoted intramolecular C-H bond cycloamination reaction. This protocol allows for the facile construction of biologically active bicyclic imidazo[1,2-alpha]pyrimidine skeletons as well as other imidazo[1,2-alpha]-type fused heterocycles.
引用
收藏
页码：4837 / 4843
页数：7
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