Hypervalent Iodine(III) Promoted Direct Synthesis of Imidazo[1,2-a]pyrimidines

被引：65

作者：

Qian, Guangyin ^{[1
]}

Liu, Bingxin ^{[1
]}

Tan, Qitao ^{[1
]}

Zhang, Siwen ^{[1
]}

Xu, Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Nitrogen heterocycles; C-H functionalization; Amination; Iodine; N BOND FORMATION; C-H AMINATION; OXIDATIVE CYCLIZATION; EFFICIENT ACCESS; DERIVATIVES; ALKENES; ARENES; CYCLOAMINATION; INHIBITORS; REACTIVITY;

D O I：

10.1002/ejoc.201402456

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and mild synthesis of imidazo[1,2-a]pyrimidine derivatives has been developed from readily available pyrimidyl arylamines or enamines through a hypervalent iodine-promoted intramolecular C-H bond cycloamination reaction. This protocol allows for the facile construction of biologically active bicyclic imidazo[1,2-alpha]pyrimidine skeletons as well as other imidazo[1,2-alpha]-type fused heterocycles.

引用

页码：4837 / 4843

页数：7

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