Biological properties and molecular targets of umbelliprenin - a mini-review

被引：55

作者：

Shakeri, Abolfazl

Iranshahy, Milad

Iranshahi, Mehrdad ^{[1
]}

机构：

[1] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 08期

关键词：

umbelliprenin; coumarin; Ferula; Apiaceae; CANCER CHEMOPREVENTIVE ACTIVITY; CELL-CYCLE ARREST; FERULA-SZOWITSIANA; PRENYLATED COUMARIN; MELANOMA CELLS; LUNG-CANCER; INHIBITORS; APOPTOSIS; BETA; 7-PRENYLOXYCOUMARINS;

D O I：

10.1080/10286020.2014.917630

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

7-Prenyloxycoumarins are a group of secondary metabolites found mainly in plants belonging to the families Rutaceae and Apiaceae. Auraptene, umbelliprenin (UM), and 7-isopentenyloxycoumarin are some examples of prenylated coumarins. UM occurs in various edible plant species including celery, coriander, angelica, lemon, and particularly, Ferula species. Although UM was isolated more than 50 years ago, its biological activities have been studied since the last two decades. Besides anticancer activities, biological activities including anti-inflammatory, antioxidant, and antileishmanial activities have been reported from this natural compound. The present mini-review deals with the biological activities and mechanism of actions reported for UM.

引用

页码：884 / 889

页数：6

共 28 条

[1] Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis [J].