The single-cell sequencing: new developments and medical applications

被引：216

作者：

Tang, Xiaoning ^{[1
,2
]}

Huang, Yongmei ^{[1
,2
]}

Lei, Jinli ^{[1
,2
]}

Luo, Hui ^{[1
,2
]}

Zhu, Xiao ^{[1
,2
]}

机构：

[1] Guangdong Med Univ, Marine Biomed Res Inst, Zhanjiang 524023, Peoples R China

[2] Guangdong Prov Zhanjiang Bay Key Lab, Zhanjiang 524023, Peoples R China

来源：

CELL AND BIOSCIENCE | 2019年 / 9卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Cancer; Clinical applications; Developments; Immunology; Single-cell sequencing technologies; Transcriptome; RNA-SEQ; NEURONAL SUBTYPES; GENOME ANALYSES; HETEROGENEITY; LANDSCAPE;

D O I：

10.1186/s13578-019-0314-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single-cell sequencing technologies and their applications in oncology, microbiology, neurology, reproduction, immunology, digestive and urinary systems, highlighting the important role that single-cell sequencing techniques play in these areas.

引用

页数：9

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