The single-cell sequencing: new developments and medical applications

被引：216
作者：
Tang, Xiaoning [1 ,2 ]
Huang, Yongmei [1 ,2 ]
Lei, Jinli [1 ,2 ]
Luo, Hui [1 ,2 ]
Zhu, Xiao [1 ,2 ]
机构：
[1] Guangdong Med Univ, Marine Biomed Res Inst, Zhanjiang 524023, Peoples R China
[2] Guangdong Prov Zhanjiang Bay Key Lab, Zhanjiang 524023, Peoples R China
来源：
CELL AND BIOSCIENCE | 2019年 / 9卷 / 1期
基金：
中国国家自然科学基金;
关键词：
Cancer; Clinical applications; Developments; Immunology; Single-cell sequencing technologies; Transcriptome; RNA-SEQ; NEURONAL SUBTYPES; GENOME ANALYSES; HETEROGENEITY; LANDSCAPE;
D O I：
10.1186/s13578-019-0314-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and evolutionary relationships of various cells. This review introduces the latest advances in single-cell sequencing technologies and their applications in oncology, microbiology, neurology, reproduction, immunology, digestive and urinary systems, highlighting the important role that single-cell sequencing techniques play in these areas.
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页数：9
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