Malignancy in Children with Trisomy 21

被引：51

作者：

Rabin, Karen R. ^{[1
]}

Whitlock, James A. ^{[2
]}

机构：

[1] Baylor Coll Med, Houston, TX 77030 USA

[2] Vanderbilt Univ, Med Ctr, Nashville, TN USA

来源：

ONCOLOGIST | 2009年 / 14卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Down syndrome; Acute lymphoblastic leukemia; Acute megakaryoblastic leukemia; Myeloproliferative disorders; GATA1 transcription factor; Janus kinase 2; ACUTE MYELOID-LEUKEMIA; ACUTE MEGAKARYOBLASTIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; TRANSIENT MYELOPROLIFERATIVE DISORDER; ONCOLOGY-GROUP COG; DOWN-SYNDROME; GENE-EXPRESSION; CLINICAL CHARACTERISTICS; MYELODYSPLASTIC SYNDROME; CYTOSINE-ARABINOSIDE;

D O I：

10.1634/theoncologist.2008-0217

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with Down syndrome (DS) display a unique spectrum of malignancies, with a 10- to 20-fold higher risk of acute leukemias, and a markedly lower incidence of solid tumors. This review discusses the current understanding of the basis for this distinctive pattern of cancer incidence and the clinical and biologic features of the malignant disorders most frequent in DS individuals: transient myeloproliferative disease, acute megakaryoblastic leukemia, and acute lymphoblastic leukemia. We also review distinctive pharmacogenetic issues, highlighting the differential chemosensitivity and toxicity profiles of DS patients compared with the general population, and epidemiologic studies of protective and adverse environmental risk factors for the development of leukemia. The Oncologist 2009; 14: 164-173

引用

页码：164 / 173

页数：10

共 91 条

[1] Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature [J].

Abildgaard, Lotte ;

Ellebaek, Eva ;

Gustafsson, Gran ;

Abrahamsson, Jonas ;

Hovi, Liisa ;

Jonmundsson, Gudmundur ;

Zeller, Bernward ;

Hasle, Henrik .

ANNALS OF HEMATOLOGY, 2006, 85 (05) :275-280

[2] Natural history of GATA1 mutations in Down syndrome [J].

Ahmed, M ;

Sternberg, A ;

Hall, G ;

Thomas, A ;

Smith, O ;

O'Marcaigh, A ;

Wynn, R ;

Stevens, R ;

Addison, M ;

King, D ;

Stewart, B ;

Gibson, B ;

Roberts, I ;

Vyas, P .

BLOOD, 2004, 103 (07) :2480-2489

[3] Long-term results of an ultra low-dose cytarabine-based regimen for the treatment of acute megakaryoblastic leukaemia in children with Down syndrome [J].

Al-Ahmari, Ali ;

Shah, Niketa ;

Sung, Lillian ;

Zipursky, Alvin ;

Hitzler, Johann .

BRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 (06) :646-648

[4] Child and maternal household chemical exposure and the risk of acute leukemia in children with Down's syndrome: A report from the children's oncology group [J].

Alderton, Lucy E. ;

Spector, Logan G. ;

Blair, Cindy K. ;

Roesler, Michelle ;

Olshan, Andrew F. ;

Robison, Leslie L. ;

Ross, Julie A. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 164 (03) :212-221

[5] Acute lymphoblastic leukemia and Down syndrome - Presenting features and treatment outcome in the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) [J].

Arico, Maurizio ;

Ziino, Ottavio ;

Valsecchi, Maria Grazia ;

Cazzaniga, Giovanni ;

Baronci, Carlo ;

Messina, Chiara ;

Pession, Andrea ;

Santoro, Nicola ;

Basso, Giuseppe ;

Conter, Valentino .

CANCER, 2008, 113 (03) :515-521

[6] Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience [J].

Athale, UH ;

Razzouk, BI ;

Raimondi, SC ;

Tong, X ;

Behm, FG ;

Head, DR ;

Srivastava, DK ;

Rubnitz, JE ;

Bowman, L ;

Pui, CH ;

Ribeiro, RC .

BLOOD, 2001, 97 (12) :3727-3732

[7]

AVANZINI MA, 1990, AM J MED GENET, P231

[8] Lymphoblast biology and outcome among children with Down syndrome and ALL treated on CCG-1952 [J].

Bassal, M ;

La, MK ;

Whitlock, JA ;

Sather, HN ;

Heerema, NA ;

Gaynon, PS ;

Stork, LC .

PEDIATRIC BLOOD & CANCER, 2005, 44 (01) :21-28

[9] Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome [J].

Bercovich, Dani ;

Ganmore, Ithamar ;

Scott, Linda M. ;

Wainreb, Gilad ;

Birger, Yehudit ;

Elimelech, Arava ;

Chen, Shochat ;

Cazzaniga, Giovanni ;

Biondi, Andrea ;

Basso, Giuseppe ;

Cario, Gunnar ;

Schrappe, Martin ;

Stanulla, Martin ;

Strehl, Sabine ;

Haas, Oskar A. ;

Mann, Georg ;

Binder, Vera ;

Borkhardt, Arndt ;

Kempski, Helena ;

Trka, Jan ;

Bielorei, Bella ;

Avigad, Smadar ;

Stark, Batia ;

Smith, Owen ;

Dastugue, Nicole ;

Bourquin, Jean-Pierre ;

Ben Tal, Nir ;

Green, Anthony R. ;

Izraeli, Shai .

LANCET, 2008, 372 (9648) :1484-1492

[10] Vitamin supplement use among children with Down's syndrome and risk of leukaemia: a Children's Oncology Group (COG) study [J].

Blair, Cindy K. ;

Roesler, Michelle ;

Xie, Yang ;

Gamis, Alan S. ;

Olshan, Andrew F. ;

Heerema, Nyla A. ;

Robison, Leslie L. ;

Ross, Julie A. .

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2008, 22 (03) :288-295

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