Antibacterial cobalt (II), copper (II), nickel (II) and zinc (II) complexes of mercaptothiadiazole-derived furanyl, thienyl, pyrrolyl, salicylyl and pyridinyl Schiff bases

被引：48

作者：

Chohan, Zahid H.

Pervez, Humayun

Rauf, Abdul

Khan, Khalid M.

Supuran, Claudiu T.

机构：

[1] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Florence, Italy

[2] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[3] Islamia Univ, Dept Chem, Bahawalpur, Pakistan

[4] Bahauddin Zakariya Univ, Dept Chem, Multan 60800, Pakistan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2006年 / 21卷 / 02期

关键词：

mercaptothiadiazoles; metal complexes; antibacterial; organometallic compounds;

D O I：

10.1080/14756360500397505

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of Co (II), Cu (II), Ni (II) and Zn (II) complexes of mercaptothiadiazole-derived furanyl, thienyl, pyrrorlyl, salicylyl and pyridinyl Schiff bases were synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella flexneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureous bacterial strains. The results of these studies show the metal complexes to be more antibacterial as compared to the prepared un-complexed Schiff bases.

引用

页码：193 / 201

页数：9

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