Genetic polymorphisms of OPRM1 on the efficacy and safety of anesthetic and analgesic agents: a systematic review

被引：4
作者：
Yee, Liew [1 ]
Capule, Francis R. [2 ]
Makmor-Bakry, Mohd [1 ]
机构：
[1] Univ Kebangsaan Malaysia, Fac Pharm, Kuala Lumpur 50300, Malaysia
[2] Univ Philippines Manila, Coll Pharm, Manila 1000, Philippines
来源：
PHARMACOGENOMICS | 2022年 / 23卷 / 10期
关键词：
A118G; anesthesia; analgesia; genetic polymorphism; OPRM1; OPIOID RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISMS; MORPHINE CONSUMPTION; A118G POLYMORPHISM; REMIFENTANIL CONSUMPTION; RESPIRATORY DEPRESSION; INTRATHECAL MORPHINE; POSTOPERATIVE PAIN; ASSOCIATION; REQUIREMENTS;
D O I：
10.2217/pgs-2022-0042
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: This systematic review aimed to outline the outcome of OPRMI (A118G) variants on the effects of anesthetic and analgesic agents used in various procedures. Materials & methods: Literature was obtained from reliable, established databases and reference tracking. Efficacy and side/adverse effects of anesthetic and analgesic drugs intraoperatively or within 48 h postsurgery were the key outcome measures for all populations. Animal studies were excluded. Results: Twenty-nine studies were chosen for inclusion. In association with the efficacy and safety of anesthetic and analgesic agents, gene polymorphism in OPRM1 displayed a strong correlation in reduced analgesic effect and protection against adverse reactions. Conclusion: This systematic review summarized the correlation between genetic polymorphism in the OPRM1 gene and anesthetic/analgesic effects.
引用
收藏
页码：609 / 617
页数：9
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