Trichomonas vaginalis: Pathogenesis, Symbiont Interactions, and Host Cell Immune Responses

被引：95

作者：

Mercer, Frances ^{[1
]}

Johnson, Patricia J. ^{[2
]}

机构：

[1] Calif State Polytech Univ Pomona, Dept Biol Sci, 3801 West Temple Ave, Pomona, CA 91768 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, 1602 Mol Sci Bldg,609 Charles E Young Dr East, Los Angeles, CA 90095 USA

来源：

TRENDS IN PARASITOLOGY | 2018年 / 34卷 / 08期

关键词：

EPITHELIAL-CELLS; INFLAMMATORY RESPONSE; BACTERIAL VAGINOSIS; ECTOCERVICAL CELLS; MYCOPLASMA-HOMINIS; UNITED-STATES; ASSOCIATION; INTERLEUKIN-8; NEUTROPHILS; INFECTIONS;

D O I：

10.1016/j.pt.2018.05.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The parasite Trichomonas vaginalis (Tv) causes a highly prevalent sexually transmitted infection. As an extracellular pathogen, the parasite mediates adherence to epithelial cells to colonize the human host. In addition, the parasite interfaces with the host immune system and the vaginal microbiota. Modes of Tv pathogenesis include damage to host tissue mediated by parasite killing of host cells, disruption of steady-state vaginal microbial ecology, and eliciting inflammation by activating the host immune response. Recent Tv research has uncovered new players that contribute to multifactorial mechanisms of host-parasite adherence and killing, and has examined the relationship between Tv and vaginal bacteria. Mechanisms that may lead to parasite recognition and killing, or the evasion of host immune cells, have also been revealed.

引用

页码：683 / 693

页数：11

共 85 条

[1] Host and tissue specificity of Trichomonas vaginalis is not mediated by its known adhesion proteins [J].

Addis, MF ;

Rappelli, P ;

Fiori, PL .

INFECTION AND IMMUNITY, 2000, 68 (07) :4358-4360

[2] Antibodies to Trichomonas vaginalis surface glycolipid [J].

Bastida-Corcuera, F. D. ;

Singh, B. N. ;

Gray, G. C. ;

Stamper, P. D. ;

Davuluri, M. ;

Schlangen, K. ;

Corbeil, R. R. ;

Corbeil, L. B. .

SEXUALLY TRANSMITTED INFECTIONS, 2013, 89 (06) :467-472

[3] The Tc1/mariner transposable element family shapes genetic variation and gene expression in the protist Trichomonas vaginalis [J].

Bradic, Martina ;

Warring, Sally D. ;

Low, Vivien ;

Carlton, Jane M. .

MOBILE DNA, 2014, 5

[4] An improved quantitative method to assess adhesive properties of Trichomonas vaginalis to host vaginal ectocervical cells using flow cytometry [J].

Brooks, Anna E. S. ;

Parsamand, Tina ;

Kelly, Robin W. ;

Simoes-Barbosa, Augusto .

JOURNAL OF MICROBIOLOGICAL METHODS, 2013, 92 (01) :73-78

[5] Association Between Trichomonas vaginalis and Vaginal Bacterial Community Composition Among Reproductive-Age Women [J].

Brotman, Rebecca M. ;

Bradford, L. Latey ;

Conrad, Melissa ;

Gajer, Pawel ;

Ault, Kevin ;

Peralta, Ligia ;

Forney, Larry J. ;

Carlton, Jane M. ;

Abdo, Zaid ;

Ravel, Jacques .

SEXUALLY TRANSMITTED DISEASES, 2012, 39 (10) :807-812

[6] Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis [J].

Carlton, Jane M. ;

Hirt, Robert P. ;

Silva, Joana C. ;

Delcher, Arthur L. ;

Schatz, Michael ;

Zhao, Qi ;

Wortman, Jennifer R. ;

Bidwell, Shelby L. ;

Alsmark, U. Cecilia M. ;

Besteiro, Sebastien ;

Sicheritz-Ponten, Thomas ;

Noel, Christophe J. ;

Dacks, Joel B. ;

Foster, Peter G. ;

Simillion, Cedric ;

Van de Peer, Yves ;

Miranda-Saavedra, Diego ;

Barton, Geoffrey J. ;

Westrop, Gareth D. ;

Mueller, Sylke ;

Dessi, Daniele ;

Fiori, Pier Luigi ;

Ren, Qinghu ;

Paulsen, Ian ;

Zhang, Hanbang ;

Bastida-Corcuera, Felix D. ;

Simoes-Barbosa, Augusto ;

Brown, Mark T. ;

Hayes, Richard D. ;

Mukherjee, Mandira ;

Okumura, Cheryl Y. ;

Schneider, Rachel ;

Smith, Alias J. ;

Vanacova, Stepanka ;

Villalvazo, Maria ;

Haas, Brian J. ;

Pertea, Mihaela ;

Feldblyum, Tamara V. ;

Utterback, Terry R. ;

Shu, Chung-Li ;

Osoegawa, Kazutoyo ;

de Jong, Pieter J. ;

Hrdy, Ivan ;

Horvathova, Lenka ;

Zubacova, Zuzana ;

Dolezal, Pavel ;

Malik, Shehre-Banoo ;

Logsdon, John M., Jr. ;

Henze, Katrin ;

Gupta, Arti .

SCIENCE, 2007, 315 (5809) :207-212

[7] Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome [J].

Chudnovskiy, Aleksey ;

Mortha, Arthur ;

Kana, Veronika ;

Kennard, Andrea ;

Ramirez, Juan David ;

Rahman, Adeeb ;

Remark, Romain ;

Mogno, Ilaria ;

Ng, Ruby ;

Gnjatic, Sasha ;

Amir, El-ad David ;

Solovyov, Alexander ;

Greenbaum, Benjamin ;

Clemente, Jose ;

Faith, Jeremiah ;

Belkaid, Yasmine ;

Grigg, Michael E. ;

Merad, Miriam .

CELL, 2016, 167 (02) :444-+

[8] The C-terminal tail of tetraspanin proteins regulates their intracellular distribution in the parasite Trichomonas vaginalis [J].

Coceres, V. M. ;

Alonso, A. M. ;

Nievas, Y. R. ;

Midlej, V. ;

Frontera, L. ;

Benchimol, M. ;

Johnson, P. J. ;

de Miguel, N. .

CELLULAR MICROBIOLOGY, 2015, 17 (08) :1217-1229

[9] Candidatus Mycoplasma girerdii replicates, diversifies, and co-occurs with Trichomonas vaginalis in the oral cavity of a premature infant [J].

Costello, Elizabeth K. ;

Sun, Christine L. ;

Carlisle, Erica M. ;

Morowitz, Michael J. ;

Banfield, Jillian F. ;

Relman, David A. .

SCIENTIFIC REPORTS, 2017, 7

[10] Proteome Analysis of the Surface of Trichomonas vaginalis Reveals Novel Proteins and Strain-dependent Differential Expression [J].

de Miguel, Natalia ;

Lustig, Gil ;

Twu, Olivia ;

Chattopadhyay, Arnab ;

Wohlschlegel, James A. ;

Johnson, Patricia J. .

MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (07) :1554-1566

← 1 2 3 4 5 6 7 8 9 →