Sensitive and predictable separation of microfluidic droplets by size using in-line passive filter

被引：14
作者：
Ding, Ruihua [1 ]
Ung, W. Lloyd [2 ]
Heyman, John A. [2 ,3 ]
Weitz, David A. [2 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
[2] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA
[3] SphereBio Inc, Somerville, MA 02143 USA
来源：
BIOMICROFLUIDICS | 2017年 / 11卷 / 01期
基金：
美国国家科学基金会;
关键词：
DETERMINISTIC LATERAL DISPLACEMENT; MICROCHANNELS; EVOLUTION; SYSTEM; DROPS;
D O I：
10.1063/1.4976723
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Active manipulation of droplets is crucial in droplet microfluidics. However, droplet polydispersity decreases the accuracy of active manipulation. We develop a microfluidic "droplet filter" that accurately separates droplets by size. The droplet filter has a sharp size cutoff and is capable of distinguishing droplets differing in volume by 20%. A simple model explains the behavior of the droplets as they pass through the filter. We show application of the filter in improving dielectric sorting efficiency. Published by AIP Publishing.
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页数：8
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