Antiproliferative sesquiterpene lactones from the roots of Inula helenium

被引：122
作者：
Konishi, T [1 ]
Shimada, Y
Nagao, T
Okabe, H
Konoshima, T
机构：
[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078414, Japan
[2] Mitsuboshi Pharmaceut Co, Nara 6392216, Japan
[3] Fukuoka Univ, Fac Pharmaceut Sci, Johnan Ku, Fukuoka 8140180, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 10期
关键词：
Inula helenium; Compositae; antiproliferative activity; sesquiterpene lactone; igalan; alantolactone;
D O I：
10.1248/bpb.25.1370
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The MeOH extract of the roots of Inula helenium showed a high inhibitory activity for cell growth against MK-1, HeLa and B16F10 cell lines. Significant activity was found in the hexane-soluble fraction. From the hexane-soluble fraction, seven sesquiterpenes, namely, one germacrane (4beta,5alpha-epoxy-1(10),11(13)-germacradiene-8,12-olide), one elemane (igalane), and five eudesmanes (alantolactone, isoalantolactone, 11alpha,13-dihydroalantolactone, 11alpha,13-dihydro-isoalantolactone, 5-epoxyalantolactone) were isolated. In vitro antiproliferative activities of the isolates against MK-1, HeLa and B16F10 cells are reported.
引用
收藏
页码：1370 / 1372
页数：3
相关论文
共 23 条
[1]  
BOHLMANN F, 1983, LIEBIGS ANN CHEM, P2227
[2]   NATURAL TERPENE DERIVATIVES .104. NEW SESQUITERPENE LACTONES AND THYMOL DERIVATIVES FROM INULA SPECIES [J].
BOHLMANN, F ;
ZDERO, C .
PHYTOCHEMISTRY, 1977, 16 (08) :1243-1245
[3]   Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa [J].
Cantrell, CL ;
Abate, L ;
Fronczek, FR ;
Franzblau, SG ;
Quijano, L ;
Fischer, NH .
PLANTA MEDICA, 1999, 65 (04) :351-355
[4]   NMR determination of the absolute configuration of an α-exo-methylene-γ-lactone [J].
Fukui, H ;
Fukushi, Y ;
Tahara, S .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (07) :1345-1351
[5]   FURTHER SESQUITERPENE LACTONES FROM COSTA RICAN EUPATORIEAE [J].
JAKUPOVIC, J ;
CASTRO, V ;
BOHLMANN, F .
PHYTOCHEMISTRY, 1987, 26 (02) :451-455
[6]  
Jiangsu New Medical College, 1986, DICT TRAD CHIN MED, P80
[7]  
KASHMAN Y, 1967, ISRAEL J CHEM, V5, P23
[8]   STEREOSTRUCTURES OF INUNAL AND ISOALLOALANTOLACTONE 2 BIOLOGICALLY-ACTIVE SESQUITERPENE LACTONES FROM INULA-RACEMOSA [J].
KAUR, B ;
KALSI, PS .
PHYTOCHEMISTRY, 1985, 24 (09) :2007-2010
[9]  
KHVOROST PP, 1976, KHIM PRIR SOEDIN+, P820
[10]  
KOWALEWSKA K, 1978, HERBA POL, V24, P107
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