Synthesis, characterization and fabrication of sodium carboxymethyl-okra-gum-grafted-polymethacrylamide into sustained release tablet matrix

The objective of the present study was to modify okra gum(Abelmoschus esculentus) by carboxymethylation and subsequent graft-copolymerization, characterize and fabricate into sustained-release tablet matrix. Firstly, okra gum was carboxymethylated using sodium hydroxide and monochloroacetic acid followed by grafting with polymethacrylamide employing synergistic combination of free-radical-initiator and microwave-irradiation. The FTIR, NMR, elemental analysis and viscosity study corroborate the formation of sodium-carboxymethylokra gum-grafted-polymethacrylamide copolymer (SCMOG-g-PMA). The maximum degree of carboxymethylsubstitution (DCS) and % grafting (%G) were found to be 0.604 +/- 0.011 and 644.1, respectively. Water-uptakecapacity was found to increase by 3.5 fold. The tablet formulation of diclofenac sodium with SCMOG-g-PMA (DCS 0.604 and 423.4% G) showed to exhibit excellent sustained-release capacity with 90% drug-release at 11.7 h and similarity-factor of 72.0. The toxicity and biodegradability study also exhibited the bio-compatible and biodegradable nature of the copolymer, which might make the copolymer suitable for sustained-release drug delivery systems as smart semi-synthetic biopolymer. (C) 2020 Elsevier B.V. All rights reserved.