Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent

被引：7
作者：
Dhotre, B. K. [1 ]
Patharia, M. A. [2 ]
Khandebharad, A. U. [3 ]
Raut, S., V [4 ]
Pathan, M. A. [4 ]
机构：
[1] Swami Vivekanand Senior Coll, Dept Chem, Mantha, Maharashtra, India
[2] NFIL Surat, Navin Res & Innovat Ctr, Surat, Gujarat, India
[3] JES Coll, Dept Chem, Jalna, Maharashtra, India
[4] Maulana Azad Coll, Dept Chem, Aurangabad, Maharashtra, India
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2020年 / 46卷 / 06期
关键词：
1,3,4-oxadiazoles; antibacterial activity; antifungal activity; molecular docking; microwave irradiation; BIOLOGICAL EVALUATION; ANTIVIRAL EVALUATION; ANTIOXIDANT;
D O I：
10.1134/S1068162020060059
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of phenyl-5-(2,3,5,6-tetrafluoro-phenyl)-[1,3,4]-oxadiazole were prepared from 2,3,5,6-tetrafluoro-benzoic acid hydrazide by treatment with various substituted benzoic acid in the presence of phosphorus oxychloride using conventional as well as microwave-assisted methods. Evaluation of antibacterial activity of synthesized compound against S. aures, S. pyogenes, S. typhi and Pseudomonas species and antifungal activity against C. albicans and A. niger has been carried out. The compounds (Vb) and (Ve) showed significant activity against both bacteria and fungi. Some of the compounds has shown moderate activity against both the bacteria and fungi. The molecular docking studies also done which support the antimicrobial activity exhibited high inhibition constant and binding energy. The chemical structures of all the synthesized compounds were elucidated by their IR, H-1 NMR and mass spectra.
引用
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页码：1110 / 1116
页数：7
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