Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium

被引：186

作者：

Trabert, Britton ^{[1
]}

Ness, Roberta B. ^{[2
]}

Lo-Ciganic, Wei-Hsuan ^{[3
]}

Murphy, Megan A. ^{[4
,6
]}

Goode, Ellen L. ^{[7
]}

Poole, Elizabeth M. ^{[4
,6
]}

Brinton, Louise A. ^{[1
]}

Webb, Penelope M. ^{[8
]}

Nagle, Christina M. ^{[8
]}

Jordan, Susan J. ^{[8
]}

Risch, Harvey A. ^{[9
]}

Rossing, Mary Anne ^{[10
]}

Doherty, Jennifer A. ^{[10
,11
]}

Goodman, Marc T. ^{[12
]}

Lurie, Galina ^{[13
]}

Kjaer, Susanne K. ^{[14
,15
]}

Hogdall, Estrid ^{[14
]}

Jensen, Allan ^{[14
]}

Cramer, Daniel W. ^{[5
,6
]}

Terry, Kathryn L. ^{[5
,6
]}

Vitonis, Allison

Bandera, Elisa V. ^{[16
]}

Olson, Sara ^{[17
]}

King, Melony G. ^{[16
]}

Chandran, Urmila ^{[16
]}

Anton-Culver, Hoda ^{[18
]}

Ziogas, Argyrios ^{[18
]}

Menon, Usha ^{[19
]}

Gayther, Simon A. ^{[20
]}

Ramus, Susan J. ^{[20
]}

Gentry-Maharaj, Aleksandra ^{[19
]}

Wu, Anna H.

Pearce, Celeste Leigh

Pike, Malcolm C. ^{[20
]}

Berchuck, Andrew ^{[21
]}

Schildkraut, Joellen M. ^{[22
,23
]}

Wentzensen, Nicolas ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD USA

[2] Univ Texas, Sch Publ Hlth, Houston, TX USA

[3] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA USA

[4] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA

[5] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA USA

[6] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[7] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[8] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[9] Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA

[10] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 USA

[11] Dartmouth Med Sch, Sect Biostat & Epidemiol, Dept Community & Family Med, Lebanon, NH USA

[12] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[13] Univ Hawaii, Canc Ctr, Canc Epidemiol Program, Honolulu, HI 96822 USA

[14] Danish Canc Soc Res Ctr, Virus Lifestyle & Genes, Copenhagen, Denmark

[15] Copenhagen Univ Hosp, Gynaecol Clin, Copenhagen, Denmark

[16] Univ Med & Dent New Jersey, Canc Inst New Jersey, New Brunswick, NJ USA

[17] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[18] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA

[19] UCL, EGA Inst Womens Hlth, Dept Womens Canc, London, England

[20] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

[21] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA

[22] Duke Univ, Med Ctr, Dept Community & Family Med, Durham, NC 27710 USA

[23] Duke Canc Inst, Canc Prevent Detect & Control Res Program, Durham, NC USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2014年 / 106卷 / 02期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

INCESSANT OVULATION; ENDOMETRIAL CANCER; PRIMARY PREVENTION; ANALGESIC DRUGS; SCREENING TRIAL; HORMONE-THERAPY; INFLAMMATION; METAANALYSIS; PROSTATE; LUNG;

D O I：

10.1093/jnci/djt431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Regular aspirin use is associated with reduced risk of several malignancies. Epidemiologic studies analyzing aspirin, nonaspirin nonsteroidal anti-inflammatory drug (NSAID), and acetaminophen use and ovarian cancer risk have been inconclusive. Methods We analyzed pooled data from 12 population-based case-control studies of ovarian cancer, including 7776 case patients and 11 843 control subjects accrued between 1992 and 2007. Odds ratios (ORs) for associations of medication use with invasive epithelial ovarian cancer were estimated in individual studies using logistic regression and combined using random effects meta-analysis. Associations between frequency, dose, and duration of analgesic use and risk of ovarian cancer were also assessed. All statistical tests were two-sided. Results Aspirin use was associated with a reduced risk of ovarian cancer (OR = 0.91; 95% confidence interval [CI] = 0.84 to 0.99). Results were similar but not statistically significant for nonaspirin NSAIDs, and there was no association with acetaminophen. In seven studies with frequency data, the reduced risk was strongest among daily aspirin users (OR = 0.80; 95% CI = 0.67 to 0.96). In three studies with dose information, the reduced risk was strongest among users of low dose (<100 mg) aspirin (OR = 0.66; 95% CI = 0.53 to 0.83), whereas for nonaspirin NSAIDs, the reduced risk was strongest for high dose (>= 500 mg) usage (OR = 0.76; 95% CI = 0.64 to 0.91). Conclusions Aspirin use was associated with a reduced risk of ovarian cancer, especially among daily users of low-dose aspirin. These findings suggest that the same aspirin regimen proven to protect against cardiovascular events and several cancers could reduce the risk of ovarian cancer 20% to 34% depending on frequency and dose of use.

引用

页数：11

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