Controversies in the management of stage III non-small-cell lung cancer

被引：17

作者：

Biswas, Tithi ^{[1
]}

Sharma, Neelesh ^{[1
]}

Machtay, Mitchell ^{[1
]}

机构：

[1] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2014年 / 14卷 / 03期

关键词：

chemoradiation; targeted therapy; non-small-cell lung cancer; adjuvant chemotherapy; trimodality therapy; LEUKEMIA-GROUP-B; RANDOMIZED PHASE-II; HYPERFRACTIONATED RADIATION-THERAPY; POSTOPERATIVE RADIOTHERAPY; PREOPERATIVE CHEMOTHERAPY; CONCURRENT CHEMOTHERAPY; INDUCTION CHEMOTHERAPY; THORACIC RADIOTHERAPY; ONCOLOGY-GROUP; ADJUVANT CHEMOTHERAPY;

D O I：

10.1586/14737140.2014.867809

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer remains the leading cause of death in the USA and is the most common cancer both in incidence and in mortality globally (1.35 million deaths annually). Non-small-cell lung cancer accounts for > 80% of all lung cancers [1]. About 35-45% of non-small-cell lung cancer patients present with locally advanced non-metastatic stage III disease. However, confirmed stage III disease represents a very heterogeneous group ranging from borderline surgical candidate with minimal mediastinal involvement to bulky mediastinal nodes or contralateral nodal involvement with significant controversy regarding optimal management in these various situations. This article specifically addresses the role of surgery, radiotherapy and chemotherapy in multimodal approach to treat stage III patients with N2/N3 involvement and controversies surrounding these recommendations.

引用

页码：333 / 347

页数：15

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