Intestinal dysbiosis: Novel mechanisms by which gut microbes trigger and prevent disease

被引:40
作者
Underwood, Mark A. [1 ]
机构
[1] UC Davis Sch Med, Div Neonatol, Sacramento, CA 95817 USA
关键词
Fusobacterium nucleatum; Colon cancer; Faecalibacterium prausnitzii; Inflammatory bowel disease; Escherichia coli Nissle 1917; Acute intestinal inflammation; Bifidobacterium infantis; Necrotizing enterocolitis; Akkermansia muciniphila; Obesity; NEONATAL NECROTIZING ENTEROCOLITIS; INFLAMMATORY-BOWEL-DISEASE; STRAIN NISSLE 1917; HUMAN-MILK OLIGOSACCHARIDES; ESCHERICHIA-COLI; FAECALIBACTERIUM-PRAUSNITZII; CROHNS-DISEASE; AKKERMANSIA-MUCINIPHILA; ULCERATIVE-COLITIS; REDUCED DIVERSITY;
D O I
10.1016/j.ypmed.2014.05.010
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
New research has identified specific intestinal colonizing microbes that can have significant influence on health and disease. Evidence is reviewed supporting an association between Fusobacterium nucleatum and colon cancer and for a protective role of Faecalibacterium prausnitzii in inflammatory bowel disease, of Escherichia coli Nissle 1917 in acute intestinal inflammation, of Bifidobacterium infantis in neonatal necrotizing enterocolitis, and of Akkermansia muciniphila in obesity and diabetes. These novel bacteria are clinically relevant and present opportunities for more focused diagnosis of colon cancer and prevention of common diseases. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:133 / 137
页数:5
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