The effects of nitroglycerin during cardiopulmonary resuscitation

被引：4

作者：

Stefaniotou, Antonia ^{[1
]}

Varvarousi, Giolanda ^{[1
]}

Varvarousis, Dimitrios P. ^{[1
]}

Xanthos, Theodoros ^{[1
]}

机构：

[1] Univ Athens, Sch Med, MSc Program Cardiopulm Resuscitat, GR-11527 Athens, Greece

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2014年 / 734卷

关键词：

Cardiac arrest; Cardiopulmonary resuscitation; Vasopressor; Nitroglycerin; Blood flow; CEREBRAL-BLOOD-FLOW; PULSELESS ELECTRICAL-ACTIVITY; FULL NEUROLOGIC RECOVERY; NITRIC-OXIDE; CARDIAC-ARREST; ORGANIC NITRATES; ISCHEMIA-REPERFUSION; PERFUSION-PRESSURE; VASOPRESSIN; EPINEPHRINE;

D O I：

10.1016/j.ejphar.2014.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocarclial and cerebral organ blood flow. Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow. Several studies suggest that combined use of nitroglycerin with vasopressors during resuscitation, is associated with increased rates of resuscitation and improved post-resuscitation outcome. This article reviews the effects of nitroglycerin during cardiopulmonary resuscitation and postresuscitation period, as well as the beneficial outcomes of a combination regimen consisting of a vasopressor and a vasodilator, such as nitroglycerin. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：42 / 49

页数：8

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