The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumor

被引:68
作者
Kauhanen, Saila [1 ,2 ]
Seppanen, Marko [1 ]
Ovaska, Jari [2 ]
Minn, Heikki [1 ,3 ]
Bergman, Jorgen [4 ]
Korsoff, Pirkko [5 ]
Salmela, Pasi [6 ]
Saltevo, Juha [7 ]
Sane, Timo [8 ]
Valimaki, Matti [8 ]
Nuutila, Pirjo [1 ,9 ]
机构
[1] Turku Univ, Cent Hosp, Turku PET Ctr, FIN-20521 Turku, Finland
[2] Turku Univ, Cent Hosp, Dept Surg, FIN-20521 Turku, Finland
[3] Turku Univ, Cent Hosp, Dept Radiotherapy & Oncol, FIN-20521 Turku, Finland
[4] Turku Univ, Radiopharmaceut Chem Lab, FIN-20521 Turku, Finland
[5] Satakunta Cent Hosp, Dept Med, Pori, Finland
[6] Oulu Univ, Cent Hosp, Dept Med, SF-90220 Oulu, Finland
[7] Cent Hosp Middle Finland, Jyvaskyla, Finland
[8] Univ Helsinki, Cent Hosp, Dept Med, Div Endocrinol, Helsinki, Finland
[9] Turku Univ, Cent Hosp, Dept Med, FIN-20521 Turku, Finland
关键词
SOMATOSTATIN RECEPTOR SCINTIGRAPHY; BETA-CELL HYPERPLASIA; CARCINOID-TUMORS; ENDOCRINE TUMORS; PET; PHEOCHROMOCYTOMAS; LOCALIZATION; CARBIDOPA; PARAGANGLIOMA; EXPRESSION;
D O I
10.1677/ERC-08-0229
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The study was set up to determine the clinical value of dihydroxyphenylalanine positron emission tomography-computed tomography ([F-18]DOPA PET-CT) in patients with neuroendocrine tumors (NETS). Eighty-two patients with suspected/known NET were imaged with PET(-CT) using [F-18] DOPA. Patients were divided into two groups: primary diagnosis/staging and restaging of disease. All patients without previous diagnosis of NET had biochemical proof of disease. The diagnostic accuracy of PET was assessed by comparing the histopathology and clinical follow-up. The overall accuracy of [F-18]DOPA PET was 90%. In patients having PET for primary diagnosis/staging (n=32), the accuracy of PET was 88%, and for restaging 92% (n=61). The mean S.D. sizes of primary and metastatic lesions detected by PET were 26 +/- 11 and 16 +/- 9 mm respectively. In organ-region-specific analysis, the sensitivity and specificity were 100% in the primary diagnosis of pheochromocytoma (n=16) and metastases were found in all cases with recurrent disease (n=5). The accuracy for NET of gastrointestinal tract was 92% in restaging (n=24). For the NETS located in the head-neck-thoracic region (n=19), the overall accuracy of PET was 89% including 12 cases of recurrent medullary thyroid cancer with a sensitivity of 90%. In analysis of patients with biochemical proof of disease combined with negative conventional imaging methods, PET had positive and negative predictive value of 92% and 95% respectively. [F-18]DOPA PET-CT provided important additional information in the diagnosis of pheochromocytoma and restaging of known NET. Both in primary diagnosis and in patients with formerly known NET and increasing tumor markers, [F-18]DOPA PET-CT is a sensitive first-line imaging method.
引用
收藏
页码:255 / 265
页数:11
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